{"data":{"id":"10.6084/m9.figshare.c.2117081.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2117081.v1","prefix":"10.6084","suffix":"m9.figshare.c.2117081.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Wang, Hao","givenName":"Hao","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Zhu, Li-Shuang","givenName":"Li-Shuang","familyName":"Zhu","affiliation":[],"nameIdentifiers":[]},{"name":"Cheng, Jin-Wei","givenName":"Jin-Wei","familyName":"Cheng","affiliation":[],"nameIdentifiers":[]},{"name":"Cai, Ji-Ping","givenName":"Ji-Ping","familyName":"Cai","affiliation":[],"nameIdentifiers":[]},{"name":"Li, You","givenName":"You","familyName":"Li","affiliation":[],"nameIdentifiers":[]},{"name":"Ma, Xiao-Ye","givenName":"Xiao-Ye","familyName":"Ma","affiliation":[],"nameIdentifiers":[]},{"name":"Wei, Rui-Li","givenName":"Rui-Li","familyName":"Wei","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Meta-analysis of Association Between the +49A/G Polymorphism of Cytotoxic T-Lymphocyte Antigen-4 and Thyroid Associated Ophthalmopathy"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Science Policy"},{"subject":"Cancer"},{"subject":"Mathematics"},{"subject":"FOS: Mathematics","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Earth and Environmental Sciences"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.c.2117081","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"\u003ci\u003ePurpose of the study\u003c/i\u003e: Cytotoxic-T lymphocyte antigen-4 (\u003ci\u003eCTLA-4\u003c/i\u003e) has been shown to play an important role in the development and progression of thyroid associated ophthalmopathy (TAO). A number of case-control studies focused on the association between \u003ci\u003eCTLA-4\u003c/i\u003e +49A/G polymorphism and risk for TAO. But the results were not always consistent. So we performed a meta-analysis to evaluate the precise association between this polymorphism and risk for TAO.\u003ci\u003eMaterials and methods\u003c/i\u003e: All publications on the association between \u003ci\u003eCTLA-4\u003c/i\u003e +49A/G polymorphism and TAO were searched in the following electronic databases: PubMed, Embase, the Cochrane library and Chinese Biomedical Literature Database, with the last report up to May 2014. This meta-analysis was assessed by Review Manager 5.1.\u003ci\u003eResults\u003c/i\u003e: A total of 14 studies were involved in this meta-analysis, including 1128 cases and 2539 controls. Overall, we found a significant association between \u003ci\u003eCTLA-4\u003c/i\u003e +49A/G polymorphism and TAO (G versus A: OR = 1.64, 95% CI = 1.40–1.92, \u003ci\u003ep\u003c/i\u003e \u0026lt; 0.00001; GG versus AG + AA: OR = 2.02, 95% CI = 1.59–2.57, \u003ci\u003ep\u003c/i\u003e \u0026lt; 0.00001; GG + AG versus AA: OR = 2.01, 95% CI = 1.66–2.43, \u003ci\u003ep\u003c/i\u003e \u0026lt; 0.00001; GG versus AA: OR = 2.74, 95% CI = 1.83–4.10, \u003ci\u003ep\u003c/i\u003e \u0026lt; 0.00001; AG versus AA: OR = 1.75, 95% CI = 1.42–2.15, \u003ci\u003ep\u003c/i\u003e \u0026lt; 0.00001). The results were not materially altered after the studies which did not fulfill Hardy–Weinberg equilibrium were excluded. Significant association was also detected in both Caucasian and Asian populations in subgroup analysis divided by different ethnicity.\u003ci\u003eConclusion\u003c/i\u003e: Our meta-analysis supports the association between the \u003ci\u003eCTLA-4\u003c/i\u003e +49A/G polymorphism and TAO.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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