{"data":{"id":"10.6084/m9.figshare.c.2116667","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2116667","prefix":"10.6084","suffix":"m9.figshare.c.2116667","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Zhao, Jin","givenName":"Jin","familyName":"Zhao","affiliation":[],"nameIdentifiers":[]},{"name":"Huang, Run-Yue","givenName":"Run-Yue","familyName":"Huang","affiliation":[],"nameIdentifiers":[]},{"name":"Li, Geng","givenName":"Geng","familyName":"Li","affiliation":[],"nameIdentifiers":[]},{"name":"Zeng, Xing","givenName":"Xing","familyName":"Zeng","affiliation":[],"nameIdentifiers":[]},{"name":"Li, Xiong","givenName":"Xiong","familyName":"Li","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Maojie","givenName":"Maojie","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Zhao, Ya","givenName":"Ya","familyName":"Zhao","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"A new coumarin isolated from \u003ci\u003eSarcandra glabra\u003c/i\u003e as potential anti-inflammatory agent"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Ecology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Chemistry"},{"subject":"Earth and Environmental Sciences"},{"subject":"Molecular Biology"},{"subject":"Genetics"},{"subject":"Cell Biology"},{"subject":"Biochemistry"},{"subject":"Biophysics"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"One new coumarin, 3,5-dihydroxy-7-O-α-L-rhamno pyranosyl-2H-chromen-2-one (\u003cb\u003e1\u003c/b\u003e), was isolated from the whole plant of \u003ci\u003eSarcandra glabra\u003c/i\u003e. The structure was elucidated by spectroscopic methods. Our results indicated that \u003cb\u003e1\u003c/b\u003e significantly inhibit nitric oxide (NO) production in LPS-induced RAW264.7 macrophages. RT-PCR analysis indicated it inhibited iNOS mRNA expression. In addition, Western blot analysis showed that \u003cb\u003e1\u003c/b\u003e attenuated LPS-induced synthesis of iNOS protein in the macrophages. These results suggest that \u003cb\u003e1\u003c/b\u003e could be potential anti-inflammatory agent by down-regulating iNOS expression.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/collections/A_new_coumarin_isolated_from_i_Sarcandra_glabra_i_as_potential_anti_inflammatory_agent/2116667","contentUrl":null,"metadataVersion":2,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2015-12-05T18:39:43.000Z","registered":"2015-12-05T18:39:44.000Z","published":"2015","updated":"2024-03-21T09:29:16.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":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