{"data":{"id":"10.6084/m9.figshare.c.2115476","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2115476","prefix":"10.6084","suffix":"m9.figshare.c.2115476","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"He, Xiaoyun","givenName":"Xiaoyun","familyName":"He","affiliation":[],"nameIdentifiers":[]},{"name":"Du, Xuezhu","givenName":"Xuezhu","familyName":"Du","affiliation":[],"nameIdentifiers":[]},{"name":"Zang, Xiangyun","givenName":"Xiangyun","familyName":"Zang","affiliation":[],"nameIdentifiers":[]},{"name":"Dong, Lili","givenName":"Lili","familyName":"Dong","affiliation":[],"nameIdentifiers":[]},{"name":"Gu, Zijian","givenName":"Zijian","familyName":"Gu","affiliation":[],"nameIdentifiers":[]},{"name":"Cao, Liping","givenName":"Liping","familyName":"Cao","affiliation":[],"nameIdentifiers":[]},{"name":"Chen, Dafu","givenName":"Dafu","familyName":"Chen","affiliation":[],"nameIdentifiers":[]},{"name":"O. Keyhani, Nemat","givenName":"Nemat","familyName":"O. Keyhani","affiliation":[],"nameIdentifiers":[]},{"name":"Yao, Lindan","givenName":"Lindan","familyName":"Yao","affiliation":[],"nameIdentifiers":[]},{"name":"Qiu, Junzhi","givenName":"Junzhi","familyName":"Qiu","affiliation":[],"nameIdentifiers":[]},{"name":"Guan, Xiong","givenName":"Xiong","familyName":"Guan","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Extraction, identification and antimicrobial activity of a new furanone, grifolaone A, from \u003ci\u003eGrifola frondosa\u003c/i\u003e"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Biochemistry"},{"subject":"Microbiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Pharmacology"},{"subject":"Environmental Sciences not elsewhere classified"},{"subject":"Chemical Sciences not elsewhere classified"},{"subject":"Ecology"},{"subject":"Sociology"},{"subject":"FOS: Sociology","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biological Sciences not elsewhere classified"},{"subject":"Developmental Biology"},{"subject":"Plant Biology"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"A furanone (\u003cb\u003e1\u003c/b\u003e), (\u003ci\u003eS\u003c/i\u003e)-methyl 2-(2-hydroxy-3,4-dimethyl-5-oxo-2,5-dihydrofuran-2-yl)acetate, was isolated from the edible mushroom \u003ci\u003eGrifola frondosa\u003c/i\u003e. Mass spectrometry and NMR analyses were used to elucidate the structure of this compound, and its absolute configuration was determined using circular dichroism spectroscopy. Compound \u003cb\u003e1\u003c/b\u003e exhibited specific antifungal activity against the plant pathogens, \u003ci\u003eFusarium oxysporum\u003c/i\u003e, \u003ci\u003eGibberella zeae\u003c/i\u003e and \u003ci\u003ePiricularia oryzae\u003c/i\u003e and the opportunistic human pathogen, \u003ci\u003ePseudallescheria boydii\u003c/i\u003e, resulting in minimum inhibitory concentration values of 2.5, 2.5, 1.25 and 0.15 μg/mL, respectively. In contrast, the furanone showed only weak activity towards \u003ci\u003eAspergillus\u003c/i\u003e spp., \u003ci\u003eCandida albicans\u003c/i\u003e and several other fungal strains tested as well as no appreciable antibacterial activity.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"PD94bWwgdmVyc2lvbj0iMS4wIiBlbmNvZGluZz0iVVRGLTgiPz4KPHJlc291cmNlIHhtbG5zPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCIgeG1sbnM6eHNpPSJodHRwOi8vd3d3LnczLm9yZy8yMDAxL1hNTFNjaGVtYS1pbnN0YW5jZSIgeHNpOnNjaGVtYUxvY2F0aW9uPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCBodHRwOi8vc2NoZW1hLmRhdGFjaXRlLm9yZy9tZXRhL2tlcm5lbC00LjQvbWV0YWRhdGEueHNkIj4KICA8aWRlbnRpZmllciBpZGVudGlmaWVyVHlwZT0iRE9JIj4xMC42MDg0L005LkZJR1NIQVJFLkMuMjExNTQ3NjwvaWRlbnRpZmllcj4KICA8Y3JlYXRvcnM+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPlhpYW95dW4gSGU8L2NyZWF0b3JOYW1lPgogICAgICA8Z2l2ZW5OYW1lPlhpYW95dW48L2dpdmVuTmFtZT4KICAgICAgPGZhbWlseU5hbWU+SGU8L2ZhbWlseU5hbWU+CiAgICA8L2NyZWF0b3I+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPlh1ZXpodSBEdTwvY3JlYXRvck5hbWU+CiAgICAgIDxnaXZlbk5hbWU+WHVlemh1PC9naXZlbk5hbWU+CiAgICAgIDxmYW1pbHlOYW1lPkR1PC9mYW1pbHlOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5YaWFuZ3l1biBaYW5nPC9jcmVhdG9yTmFtZT4KICAgICAgPGdpdmVuTmFtZT5YaWFuZ3l1bjwvZ2l2ZW5OYW1lPgogICAgICA8ZmFtaWx5TmFtZT5aYW5nPC9mYW1pbHlOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5MaWxpIERvbmc8L2NyZWF0b3JOYW1lPgogICAgICA8Z2l2ZW5OYW1lPkxpbGk8L2dpdmVuTmFtZT4KICAgICAgPGZhbWlseU5hbWU+RG9uZzwvZmFtaWx5TmFtZT4KICAgIDwvY3JlYXRvcj4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+WmlqaWFuIEd1PC9jcmVhdG9yTmFtZT4KICAgICAgPGdpdmVuTmFtZT5aaWppYW48L2dpdmVuTmFtZT4KICAgICAgPGZhbWlseU5hbWU+R3U8L2ZhbWlseU5hbWU+CiAgICA8L2NyZWF0b3I+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPkxpcGluZyBDYW88L2NyZWF0b3JOYW1lPgogICAgICA8Z2l2ZW5OYW1lPkxpcGluZzwvZ2l2ZW5OYW1lPgogICAgICA8ZmFtaWx5TmFtZT5DYW88L2ZhbWlseU5hbWU+CiAgICA8L2NyZWF0b3I+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPkRhZnUgQ2hlbjwvY3JlYXRvck5hbWU+CiAgICAgIDxnaXZlbk5hbWU+RGFmdTwvZ2l2ZW5OYW1lPgogICAgICA8ZmFtaWx5TmFtZT5DaGVuPC9mYW1pbHlOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5OZW1hdCBPLiBLZXloYW5pPC9jcmVhdG9yTmFtZT4KICAgICAgPGdpdmVuTmFtZT5OZW1hdDwvZ2l2ZW5OYW1lPgogICAgICA8ZmFtaWx5TmFtZT5PLiBLZXloYW5pPC9mYW1pbHlOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5MaW5kYW4gWWFvPC9jcmVhdG9yTmFtZT4KICAgICAgPGdpdmVuTmFtZT5MaW5kYW48L2dpdmVuTmFtZT4KICAgICAgPGZhbWlseU5hbWU+WWFvPC9mYW1pbHlOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5KdW56aGkgUWl1PC9jcmVhdG9yTmFtZT4KICAgICAgPGdpdmVuTmFtZT5KdW56aGk8L2dpdmVuTmFtZT4KICAgICAgPGZhbWlseU5hbWU+UWl1PC9mYW1pbHlOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5YaW9uZyBHdWFuPC9jcmVhdG9yTmFtZT4KICAgICAgPGdpdmVuTmFtZT5YaW9uZzwvZ2l2ZW5OYW1lPgogICAgICA8ZmFtaWx5TmFtZT5HdWFuPC9mYW1pbHlOYW1lPgogICAgPC9jcmVhdG9yPgogIDwvY3JlYXRvcnM+CiAgPHRpdGxlcz4KICAgIDx0aXRsZT5FeHRyYWN0aW9uLCBpZGVudGlmaWNhdGlvbiBhbmQgYW50aW1pY3JvYmlhbCBhY3Rpdml0eSBvZiBhIG5ldyBmdXJhbm9uZSwgZ3JpZm9sYW9uZSBBLCBmcm9tICZsdDtpJmd0O0dyaWZvbGEgZnJvbmRvc2EmbHQ7L2kmZ3Q7PC90aXRsZT4KICA8L3RpdGxlcz4KICA8ZGVzY3JpcHRpb25zPgogICAgPGRlc2NyaXB0aW9uIGRlc2NyaXB0aW9uVHlwZT0iQWJzdHJhY3QiPiZsdDtwJmd0O0EgZnVyYW5vbmUgKCZsdDtiJmd0OzEmbHQ7L2ImZ3Q7KSwgKCZsdDtpJmd0O1MmbHQ7L2kmZ3Q7KS1tZXRoeWwgMi0oMi1oeWRyb3h5LTMsNC1kaW1ldGh5bC01LW94by0yLDUtZGloeWRyb2Z1cmFuLTIteWwpYWNldGF0ZSwgd2FzIGlzb2xhdGVkIGZyb20gdGhlIGVkaWJsZSBtdXNocm9vbSAmbHQ7aSZndDtHcmlmb2xhIGZyb25kb3NhJmx0Oy9pJmd0Oy4gTWFzcyBzcGVjdHJvbWV0cnkgYW5kIE5NUiBhbmFseXNlcyB3ZXJlIHVzZWQgdG8gZWx1Y2lkYXRlIHRoZSBzdHJ1Y3R1cmUgb2YgdGhpcyBjb21wb3VuZCwgYW5kIGl0cyBhYnNvbHV0ZSBjb25maWd1cmF0aW9uIHdhcyBkZXRlcm1pbmVkIHVzaW5nIGNpcmN1bGFyIGRpY2hyb2lzbSBzcGVjdHJvc2NvcHkuIENvbXBvdW5kICZsdDtiJmd0OzEmbHQ7L2ImZ3Q7IGV4aGliaXRlZCBzcGVjaWZpYyBhbnRpZnVuZ2FsIGFjdGl2aXR5IGFnYWluc3QgdGhlIHBsYW50IHBhdGhvZ2VucywgJmx0O2kmZ3Q7RnVzYXJpdW0gb3h5c3BvcnVtJmx0Oy9pJmd0OywgJmx0O2kmZ3Q7R2liYmVyZWxsYSB6ZWFlJmx0Oy9pJmd0OyBhbmQgJmx0O2kmZ3Q7UGlyaWN1bGFyaWEgb3J5emFlJmx0Oy9pJmd0OyBhbmQgdGhlIG9wcG9ydHVuaXN0aWMgaHVtYW4gcGF0aG9nZW4sICZsdDtpJmd0O1BzZXVkYWxsZXNjaGVyaWEgYm95ZGlpJmx0Oy9pJmd0OywgcmVzdWx0aW5nIGluIG1pbmltdW0gaW5oaWJpdG9yeSBjb25jZW50cmF0aW9uIHZhbHVlcyBvZiAyLjUsIDIuNSwgMS4yNSBhbmQgMC4xNcKgzrxnL21MLCByZXNwZWN0aXZlbHkuIEluIGNvbnRyYXN0LCB0aGUgZnVyYW5vbmUgc2hvd2VkIG9ubHkgd2VhayBhY3Rpdml0eSB0b3dhcmRzICZsdDtpJmd0O0FzcGVyZ2lsbHVzJmx0Oy9pJmd0OyBzcHAuLCAmbHQ7aSZndDtDYW5kaWRhIGFsYmljYW5zJmx0Oy9pJmd0OyBhbmQgc2V2ZXJhbCBvdGhlciBmdW5nYWwgc3RyYWlucyB0ZXN0ZWQgYXMgd2VsbCBhcyBubyBhcHByZWNpYWJsZSBhbnRpYmFjdGVyaWFsIGFjdGl2aXR5LiZsdDsvcCZndDs8L2Rlc2NyaXB0aW9uPgogIDwvZGVzY3JpcHRpb25zPgogIDxzdWJqZWN0cz4KICAgIDxzdWJqZWN0PkJpb2NoZW1pc3RyeTwvc3ViamVjdD4KICAgIDxzdWJqZWN0Pk1pY3JvYmlvbG9neTwvc3ViamVjdD4KICAgIDxzdWJqZWN0PlBoYXJtYWNvbG9neTwvc3ViamVjdD4KICAgIDxzdWJqZWN0PkVudmlyb25tZW50YWwgU2NpZW5jZXMgbm90IGVsc2V3aGVyZSBjbGFzc2lmaWVkPC9zdWJqZWN0PgogICAgPHN1YmplY3Q+Q2hlbWljYWwgU2NpZW5jZXMgbm90IGVsc2V3aGVyZSBjbGFzc2lmaWVkPC9zdWJqZWN0PgogICAgPHN1YmplY3Q+RWNvbG9neTwvc3ViamVjdD4KICAgIDxzdWJqZWN0PlNvY2lvbG9neTwvc3ViamVjdD4KICAgIDxzdWJqZWN0PkJpb2xvZ2ljYWwgU2NpZW5jZXMgbm90IGVsc2V3aGVyZSBjbGFzc2lmaWVkPC9zdWJqZWN0PgogICAgPHN1YmplY3Q+RGV2ZWxvcG1lbnRhbCBCaW9sb2d5PC9zdWJqZWN0PgogICAgPH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