{"data":{"id":"10.6084/m9.figshare.c.2115452","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2115452","prefix":"10.6084","suffix":"m9.figshare.c.2115452","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Yang, Guang","givenName":"Guang","familyName":"Yang","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Baohuan","givenName":"Baohuan","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Huang, Weihuang","givenName":"Weihuang","familyName":"Huang","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Na","givenName":"Na","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Dong, Fang","givenName":"Fang","familyName":"Dong","affiliation":[],"nameIdentifiers":[]},{"name":"Jing, Lipeng","givenName":"Lipeng","familyName":"Jing","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Man","givenName":"Man","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Liu, Yang","givenName":"Yang","familyName":"Liu","affiliation":[],"nameIdentifiers":[]},{"name":"Guo, Congcong","givenName":"Congcong","familyName":"Guo","affiliation":[],"nameIdentifiers":[]},{"name":"Pan, Hongwei","givenName":"Hongwei","familyName":"Pan","affiliation":[],"nameIdentifiers":[]},{"name":"Wei, Xiangcai","givenName":"Xiangcai","familyName":"Wei","affiliation":[],"nameIdentifiers":[]},{"name":"Jing, Chunxia","givenName":"Chunxia","familyName":"Jing","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Systematic review and meta-analysis of the association between IL18RAP rs917997 and CCR3 rs6441961 polymorphisms with celiac disease risks"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Science Policy"},{"subject":"Cancer"},{"subject":"Mathematics"},{"subject":"FOS: Mathematics","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biological Sciences"},{"subject":"Ecology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Earth and Environmental Sciences"},{"subject":"Biotechnology"},{"subject":"Medicine"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Objectives: We performed a systematic review and meta-analysis to estimate the polymorphism effects of IL18RAP and CCR3 on celiac disease susceptibility. Methods: PubMed and Web of Science databases were searched (to June 2015) on IL18RAP rs917997 and CCR3 rs6441961 polymorphisms. Results: The meta-analysis included 16 and 7 studies for rs917997 and rs6441961, respectively. The minor risk A allele at both rs917997 and rs6441961 carried risks (odds ratios) of 1.24 (95% CI 1.18–1.31) and 1.21 (95% CI 1.12–1.31), respectively. These alleles contributed to increase risks in all celiac disease patients by 5.04 and 6.35%. The estimated lambdas were 0.73 and 0.51, suggesting that an additive model would be the best choice for both gene effects. Conclusions: This meta-analysis provides robust estimates that IL18RAP rs917997 and CCR3 rs6441961 are potential risk factors for celiac disease in European populations. Studies are needed to confirm these findings in different ethnicities.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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