{"data":{"id":"10.6084/m9.figshare.c.2115392","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2115392","prefix":"10.6084","suffix":"m9.figshare.c.2115392","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Kothari, Nishi","givenName":"Nishi","familyName":"Kothari","affiliation":[],"nameIdentifiers":[]},{"name":"Kothari, Nishi","givenName":"Nishi","familyName":"Kothari","affiliation":[],"nameIdentifiers":[]},{"name":"Kim, Richard","givenName":"Richard","familyName":"Kim","affiliation":[],"nameIdentifiers":[]},{"name":"N. Jorissen, Robert","givenName":"Robert","familyName":"N. Jorissen","affiliation":[],"nameIdentifiers":[]},{"name":"Desai, Jayesh","givenName":"Jayesh","familyName":"Desai","affiliation":[],"nameIdentifiers":[]},{"name":"Desai, Jayesh","givenName":"Jayesh","familyName":"Desai","affiliation":[],"nameIdentifiers":[]},{"name":"Tie, Jeanne","givenName":"Jeanne","familyName":"Tie","affiliation":[],"nameIdentifiers":[]},{"name":"Wong, Hui-Li","givenName":"Hui-Li","familyName":"Wong","affiliation":[],"nameIdentifiers":[]},{"name":"Wong, Hui-Li","givenName":"Hui-Li","familyName":"Wong","affiliation":[],"nameIdentifiers":[]},{"name":"Farragher, Ian","givenName":"Ian","familyName":"Farragher","affiliation":[],"nameIdentifiers":[]},{"name":"Farragher, Ian","givenName":"Ian","familyName":"Farragher","affiliation":[],"nameIdentifiers":[]},{"name":"Jones, Ian","givenName":"Ian","familyName":"Jones","affiliation":[],"nameIdentifiers":[]},{"name":"L. Day, Fiona","givenName":"Fiona","familyName":"L. Day","affiliation":[],"nameIdentifiers":[]},{"name":"L. Day, Fiona","givenName":"Fiona","familyName":"L. Day","affiliation":[],"nameIdentifiers":[]},{"name":"Li, Shan","givenName":"Shan","familyName":"Li","affiliation":[],"nameIdentifiers":[]},{"name":"Sakthinandeswaren, Anuratha","givenName":"Anuratha","familyName":"Sakthinandeswaren","affiliation":[],"nameIdentifiers":[]},{"name":"Sakthinandeswaren, Anuratha","givenName":"Anuratha","familyName":"Sakthinandeswaren","affiliation":[],"nameIdentifiers":[]},{"name":"Palmieri, Michelle","givenName":"Michelle","familyName":"Palmieri","affiliation":[],"nameIdentifiers":[]},{"name":"Palmieri, Michelle","givenName":"Michelle","familyName":"Palmieri","affiliation":[],"nameIdentifiers":[]},{"name":"Lipton, Lara","givenName":"Lara","familyName":"Lipton","affiliation":[],"nameIdentifiers":[]},{"name":"Schell, Michael","givenName":"Michael","familyName":"Schell","affiliation":[],"nameIdentifiers":[]},{"name":"Schell, Michael","givenName":"Michael","familyName":"Schell","affiliation":[],"nameIdentifiers":[]},{"name":"K. Teer, Jamie","givenName":"Jamie","familyName":"K. Teer","affiliation":[],"nameIdentifiers":[]},{"name":"Shibata, David","givenName":"David","familyName":"Shibata","affiliation":[],"nameIdentifiers":[]},{"name":"Yeatman, Timothy","givenName":"Timothy","familyName":"Yeatman","affiliation":[],"nameIdentifiers":[]},{"name":"M. Sieber, Oliver","givenName":"Oliver","familyName":"M. Sieber","affiliation":[],"nameIdentifiers":[]},{"name":"Gibbs, Peter","givenName":"Peter","familyName":"Gibbs","affiliation":[],"nameIdentifiers":[]},{"name":"Tran, Ben","givenName":"Ben","familyName":"Tran","affiliation":[],"nameIdentifiers":[]},{"name":"Tran, Ben","givenName":"Ben","familyName":"Tran","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Impact of regular aspirin use on overall and cancer-specific survival in patients with colorectal cancer harboring a PIK3CA mutation"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Cancer"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biotechnology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Medicine"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"\u003cb\u003eBackground.\u003c/b\u003e Recent data have suggested that regular aspirin use improves overall and cancer-specific survival in the subset of colorectal cancer (CRC) patients harboring \u003ci\u003ePIK3CA\u003c/i\u003e mutations. However, the number of \u003ci\u003ePIK3CA\u003c/i\u003e-mutated CRC patients examined in these studies was modest. Our collaborative study aims to validate the association between regular aspirin use and survival in patients with \u003ci\u003ePIK3CA\u003c/i\u003e-mutated CRC.\u003cb\u003ePatients and methods.\u003c/b\u003e Patients with \u003ci\u003ePIK3CA\u003c/i\u003e-mutated CRC were identified at Moffitt Cancer Center (MCC) in the United States and Royal Melbourne Hospital (RMH) in Australia. Prospective clinicopathological data and survival data were available. At MCC, \u003ci\u003ePIK3CA\u003c/i\u003e mutations were identified by targeted exome sequencing using the Illumina GAIIx Next Generation Sequencing platform. At RMH, Sanger sequencing was utilized. Multivariate survival analyses were conducted using Cox logistic regression.\u003cb\u003eResults.\u003c/b\u003e From a cohort of 1487 CRC patients, 185 patients harbored a \u003ci\u003ePIK3CA\u003c/i\u003e mutation. Median age of patients with PIK3CA-mutated tumors was 72 years (range: 34–92) and median follow up was 54 months. Forty-nine (26%) patients used aspirin regularly. Regular aspirin use was not associated with improved overall survival (multivariate HR 0.96, p = 0.86). There was a trend towards improved cancer-specific survival (multivariate HR 0.60, p = 0.14), but this was not significant.\u003cb\u003eConclusions.\u003c/b\u003e Despite examining a large number of patients, we did not confirm that regular aspirin use was associated with statistically significant improvements in survival in PIK3CA-mutated CRC patients. Prospective evaluation of this relationship is warranted.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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  <identifier identifierType="DOI">10.6084/M9.FIGSHARE.C.2115392</identifier>
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    <creator>
      <creatorName>Nishi Kothari</creatorName>
      <givenName>Nishi</givenName>
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    <creator>
      <creatorName>Nishi Kothari</creatorName>
      <givenName>Nishi</givenName>
      <familyName>Kothari</familyName>
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      <creatorName>Richard Kim</creatorName>
      <givenName>Richard</givenName>
      <familyName>Kim</familyName>
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    <creator>
      <creatorName>Robert N. Jorissen</creatorName>
      <givenName>Robert</givenName>
      <familyName>N. Jorissen</familyName>
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      <creatorName>Jayesh Desai</creatorName>
      <givenName>Jayesh</givenName>
      <familyName>Desai</familyName>
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    <creator>
      <creatorName>Jayesh Desai</creatorName>
      <givenName>Jayesh</givenName>
      <familyName>Desai</familyName>
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    <creator>
      <creatorName>Jeanne Tie</creatorName>
      <givenName>Jeanne</givenName>
      <familyName>Tie</familyName>
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    <creator>
      <creatorName>Hui-Li Wong</creatorName>
      <givenName>Hui-Li</givenName>
      <familyName>Wong</familyName>
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    <creator>
      <creatorName>Hui-Li Wong</creatorName>
      <givenName>Hui-Li</givenName>
      <familyName>Wong</familyName>
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      <creatorName>Ian Farragher</creatorName>
      <givenName>Ian</givenName>
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      <creatorName>Ian Farragher</creatorName>
      <givenName>Ian</givenName>
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      <creatorName>Ian Jones</creatorName>
      <givenName>Ian</givenName>
      <familyName>Jones</familyName>
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      <creatorName>Fiona L. Day</creatorName>
      <givenName>Fiona</givenName>
      <familyName>L. Day</familyName>
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      <creatorName>Fiona L. Day</creatorName>
      <givenName>Fiona</givenName>
      <familyName>L. Day</familyName>
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      <creatorName>Shan Li</creatorName>
      <givenName>Shan</givenName>
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      <creatorName>Anuratha Sakthinandeswaren</creatorName>
      <givenName>Anuratha</givenName>
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    <creator>
      <creatorName>Anuratha Sakthinandeswaren</creatorName>
      <givenName>Anuratha</givenName>
      <familyName>Sakthinandeswaren</familyName>
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    <creator>
      <creatorName>Michelle Palmieri</creatorName>
      <givenName>Michelle</givenName>
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    <creator>
      <creatorName>Michelle Palmieri</creatorName>
      <givenName>Michelle</givenName>
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      <creatorName>Lara Lipton</creatorName>
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      <creatorName>Michael Schell</creatorName>
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      <creatorName>Michael Schell</creatorName>
      <givenName>Michael</givenName>
      <familyName>Schell</familyName>
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      <creatorName>Jamie K. Teer</creatorName>
      <givenName>Jamie</givenName>
      <familyName>K. Teer</familyName>
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    <creator>
      <creatorName>David Shibata</creatorName>
      <givenName>David</givenName>
      <familyName>Shibata</familyName>
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    <creator>
      <creatorName>Timothy Yeatman</creatorName>
      <givenName>Timothy</givenName>
      <familyName>Yeatman</familyName>
    </creator>
    <creator>
      <creatorName>Oliver M. Sieber</creatorName>
      <givenName>Oliver</givenName>
      <familyName>M. Sieber</familyName>
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    <creator>
      <creatorName>Peter Gibbs</creatorName>
      <givenName>Peter</givenName>
      <familyName>Gibbs</familyName>
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    <creator>
      <creatorName>Ben Tran</creatorName>
      <givenName>Ben</givenName>
      <familyName>Tran</familyName>
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    <creator>
      <creatorName>Ben Tran</creatorName>
      <givenName>Ben</givenName>
      <familyName>Tran</familyName>
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  <titles>
    <title>Impact of regular aspirin use on overall and cancer-specific survival in patients with colorectal cancer harboring a PIK3CA mutation</title>
  </titles>
  <descriptions>
    <description descriptionType="Abstract">&lt;div&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Background.&lt;/b&gt; Recent data have suggested that regular aspirin use improves overall and cancer-specific survival in the subset of colorectal cancer (CRC) patients harboring &lt;i&gt;PIK3CA&lt;/i&gt; mutations. However, the number of &lt;i&gt;PIK3CA&lt;/i&gt;-mutated CRC patients examined in these studies was modest. Our collaborative study aims to validate the association between regular aspirin use and survival in patients with &lt;i&gt;PIK3CA&lt;/i&gt;-mutated CRC.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Patients and methods.&lt;/b&gt; Patients with &lt;i&gt;PIK3CA&lt;/i&gt;-mutated CRC were identified at Moffitt Cancer Center (MCC) in the United States and Royal Melbourne Hospital (RMH) in Australia. Prospective clinicopathological data and survival data were available. At MCC, &lt;i&gt;PIK3CA&lt;/i&gt; mutations were identified by targeted exome sequencing using the Illumina GAIIx Next Generation Sequencing platform. At RMH, Sanger sequencing was utilized. Multivariate survival analyses were conducted using Cox logistic regression.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results.&lt;/b&gt; From a cohort of 1487 CRC patients, 185 patients harbored a &lt;i&gt;PIK3CA&lt;/i&gt; mutation. Median age of patients with PIK3CA-mutated tumors was 72 years (range: 34–92) and median follow up was 54 months. Forty-nine (26%) patients used aspirin regularly. Regular aspirin use was not associated with improved overall survival (multivariate HR 0.96, p = 0.86). There was a trend towards improved cancer-specific survival (multivariate HR 0.60, p = 0.14), but this was not significant.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions.&lt;/b&gt; Despite examining a large number of patients, we did not confirm that regular aspirin use was associated with statistically significant improvements in survival in PIK3CA-mutated CRC patients. Prospective evaluation of this relationship is warranted.&lt;/p&gt;&lt;/div&gt;</description>
  </descriptions>
  <subjects>
    <subject>Cancer</subject>
    <subject>Biological Sciences</subject>
    <subject>Immunology</subject>
    <subject>Biotechnology</subject>
    <subject>Genetics</subject>
    <subject>Cell Biology</subject>
    <subject>Medicine</subject>
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  <publisher>Taylor &amp; Francis</publisher>
  <publicationYear>2015</publicationYear>
  <dates>
    <date dateType="Created">2015-12-05</date>
    <date dateType="Updated">2019-08-19</date>
  </dates>
  <resourceType resourceTypeGeneral="Collection">Collection</resourceType>
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    <rights rightsURI="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0</rights>
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