{"data":{"id":"10.6084/m9.figshare.c.2114960.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2114960.v1","prefix":"10.6084","suffix":"m9.figshare.c.2114960.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Cao, GuiQun","givenName":"GuiQun","familyName":"Cao","affiliation":[],"nameIdentifiers":[]},{"name":"Chen, Yulong","givenName":"Yulong","familyName":"Chen","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Jinlong","givenName":"Jinlong","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Liu, Yulan","givenName":"Yulan","familyName":"Liu","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Ming","givenName":"Ming","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Kang","givenName":"Kang","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Su, Zhiguang","givenName":"Zhiguang","familyName":"Su","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Effects of adiponectin polymorphisms on the risk of advanced age-related macular degeneration"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Mathematics"},{"subject":"FOS: Mathematics","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biological Sciences"},{"subject":"Ecology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Earth and Environmental Sciences"},{"subject":"Biotechnology"},{"subject":"Physiology"},{"subject":"Genetics"},{"subject":"Medicine"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.c.2114960","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"\u003ci\u003eObjective\u003c/i\u003e: To determine the relationships between variants in adiponectin gene (\u003ci\u003eADIPOQ\u003c/i\u003e) with advanced forms of age-related macular degeneration (AMD) susceptibility.\u003ci\u003eMethods\u003c/i\u003e: A total of 189 advanced AMD patients and 168 controls were recruited. Seven tagging single-nucleotide polymorphisms in \u003ci\u003eADIPOQ\u003c/i\u003e were genotyped by the SNaPshot method.\u003ci\u003eResults\u003c/i\u003e: Alleles or genotypes of rs822396 distributed significantly differently in advanced AMD patients and controls. The minor allele G at rs822396 was associated with an increased risk of advanced AMD in a dominant model. Furthermore, haplotype analysis revealed that haplotypes AGGACCT and TGACCCC were significantly increased the advanced AMD susceptibility, whereas haplotypes AGAACGC, TGAACGT and TGACAGC had protective effects.\u003ci\u003eConclusion\u003c/i\u003e: \u003ci\u003eADIPOQ\u003c/i\u003e genetic variant rs822396 might affect an individual’s susceptibility to AMD, making it efficient genetic biomarkers for early detection of AMD.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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