{"data":{"id":"10.6084/m9.figshare.c.2114573","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2114573","prefix":"10.6084","suffix":"m9.figshare.c.2114573","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Sasongko, Muhammad Bayu","nameType":"Personal","givenName":"Muhammad Bayu","familyName":"Sasongko","affiliation":[],"nameIdentifiers":[]},{"name":"Wong, Tien Yin","nameType":"Personal","givenName":"Tien Yin","familyName":"Wong","affiliation":[],"nameIdentifiers":[]},{"name":"Nguyen, Thanh T.","nameType":"Personal","givenName":"Thanh T.","familyName":"Nguyen","affiliation":[],"nameIdentifiers":[]},{"name":"Cheung, Carol Y.","nameType":"Personal","givenName":"Carol Y.","familyName":"Cheung","affiliation":[],"nameIdentifiers":[]},{"name":"Shaw, Jonathan E.","nameType":"Personal","givenName":"Jonathan E.","familyName":"Shaw","affiliation":[],"nameIdentifiers":[]},{"name":"Kawasaki, Ryo","nameType":"Personal","givenName":"Ryo","familyName":"Kawasaki","affiliation":[],"nameIdentifiers":[]},{"name":"Ecosse L. Lamoureux","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Jie Jin","nameType":"Personal","givenName":"Jie Jin","familyName":"Wang","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Retinal Vessel Tortuosity and Its Relation to Traditional and Novel Vascular Risk Markers in Persons with Diabetes"}],"publisher":"Figshare","container":{},"publicationYear":2015,"subjects":[{"subject":"Medicine"},{"subject":"Cell Biology"},{"subject":"Neuroscience"},{"subject":"Physiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biotechnology"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"69999 Biological Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"Developmental Biology"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2016-04-28","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"CC-BY","rightsUri":"http://creativecommons.org/licenses/by/3.0/us"}],"descriptions":[{"description":"\u003ci\u003ePurpose/Aim\u003c/i\u003e: To investigate the association between retinal vascular tortuosity and traditional- and vascular-related risk factors in persons with diabetes. \u003ci\u003eMethods\u003c/i\u003e: We recruited 224 diabetic patients. Retinal vascular tortuosity was measured from fundus photographs. Association of tortuosity with the following factors was assessed after adjusting for significant co-factors: diabetes duration, HbA1c, systolic blood pressure (SBP), cholesterol and body mass index (BMI), flicker-light induced retinal vasodilatation, and markers of endothelial function and inflammation (skin microvacular responses to acetylcholine iontophoresis, soluble e-selectin, inter-cellular adhesion molecule-1, vascular cell adhesion molecule-1, endothelin-1, total nitrite, C-reactive protein). \u003ci\u003eResults\u003c/i\u003e: Adjusting for age and gender, longer diabetes duration was associated with more tortuous retinal arterioles (mean difference in arteriolar tortuosity 5.85 × 10\u003csup\u003e−5\u003c/sup\u003e, 95% Confidence Interval 1.44–10.3 × 10\u003csup\u003e−5\u003c/sup\u003e; \u003ci\u003ep\u003c/i\u003e = 0.016; ≤10 versus \u0026gt;10 years duration). Reduced flicker-light induced retinal vasodilatation was associated with tortuous arterioles and venules (mean difference in arteriolar tortuosity 5.62 × 10\u003csup\u003e−5\u003c/sup\u003e, 4.50–6.72 × 10\u003csup\u003e−5\u003c/sup\u003e; \u003ci\u003ep \u003c/i\u003e−5, 3.33–8.55 × 10\u003csup\u003e−5\u003c/sup\u003e; \u003ci\u003ep \u003c/i\u003e \u003ci\u003eConclusions\u003c/i\u003e: Increased retinal arteriolar tortuosity was related to longer diabetes duration and reduced flicker-light induced vasodilatory response, suggesting that retinal vascular tortuosity in adults with diabetes may be influenced by multiple diabetes-related physio-pathological changes.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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