{"data":{"id":"10.6084/m9.figshare.c.2113466","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2113466","prefix":"10.6084","suffix":"m9.figshare.c.2113466","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Lin, Hao","givenName":"Hao","familyName":"Lin","affiliation":[],"nameIdentifiers":[]},{"name":"Huang, Ju","givenName":"Ju","familyName":"Huang","affiliation":[],"nameIdentifiers":[]},{"name":"Hong, YingKai","givenName":"YingKai","familyName":"Hong","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"\u003ci\u003eIn vitro\u003c/i\u003e anti-tumor activity of the tanshinone IIA against SKOV3 cells"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Hematology"},{"subject":"Cancer"},{"subject":"Developmental Biology"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Chemistry"},{"subject":"Molecular Biology"},{"subject":"Cell Biology"},{"subject":"Biochemistry"},{"subject":"Biophysics"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"The aim of this study was to determine the anti-tumour activity of tanshinone IIA in SKOV3 cells. Results suggested that tanshinone IIA could significantly inhibit (IC\u003csub\u003e50\u003c/sub\u003e value  =  19.6 μM) the proliferation and induce apoptosis of SKOV3 cells as demonstrated by flow cytometry analysis. In addition, tanshinone IIA treatment induced G2/M phase cell cycle arrest in SKOV3 cells. The results of Western blotting indicated that tanshinone IIA can suppress the expression of anti-apoptotic protein Bcl-2, increase (0.28 vs. 0.62) the expression of pro-apoptotic protein Bax (0.83 vs. 0.24) in SKOV3 cells. It can be concluded that the tanshinone IIA may be a possible therapeutic candidate having cytotoxic and anti-tumour potential.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/collections/_i_In_vitro_i_anti_tumor_activity_of_the_tanshinone_IIA_against_SKOV3_cells/2113466","contentUrl":null,"metadataVersion":2,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2015-12-05T18:25:41.000Z","registered":"2015-12-05T18:25:42.000Z","published":"2015","updated":"2024-03-21T11:24:06.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.c.2113466","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}