{"data":{"id":"10.6084/m9.figshare.c.2112605.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2112605.v1","prefix":"10.6084","suffix":"m9.figshare.c.2112605.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Luo, Yonglun","givenName":"Yonglun","familyName":"Luo","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Kangli","givenName":"Kangli","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Yan","givenName":"Yan","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Xiaolin","givenName":"Xiaolin","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Teng, Huajing","givenName":"Huajing","familyName":"Teng","affiliation":[],"nameIdentifiers":[]},{"name":"Sun, Zhongsheng","givenName":"Zhongsheng","familyName":"Sun","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Jiesi","givenName":"Jiesi","familyName":"Wang","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Clock-controlled StAR’s expression and corticosterone production contribute to the endotoxemia immune response"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Mental Health"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Meta Science"},{"subject":"Physiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Genetics"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.c.2112605","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Increased studies have revealed that core mammalian clock genes regulate immune functions. Previously, we reported \u003ci\u003ePer2\u003c/i\u003e\u003csup\u003em/m\u003c/sup\u003e mice displayed a down-regulated circadian immune response to lipopolysaccharide (LPS) challenge. However, the mediators between \u003ci\u003ePer2\u003c/i\u003e and immune function and their underlying mechanisms remain unclear. In this study, serum corticosterone (CORT), a hormone which played a crucial role in immune suppression, was found to be significantly increased in \u003ci\u003ePer2\u003c/i\u003e\u003csup\u003em/m\u003c/sup\u003e mice compared with the one in wild-type mice following LPS administration at ZT3 and ZT8. The elevated level of serum CORT was correlated with their higher survival rate, which could be further suppressed by glucocorticoid receptor antagonist. Expression of StAR, a rate-limiting enzyme in CORT synthesis, as well as the expression of core clock genes (\u003ci\u003eClock/Bmal1)\u003c/i\u003e, was more strongly induced and longer lasting in \u003ci\u003ePer2\u003c/i\u003e\u003csup\u003em/m\u003c/sup\u003e mice in contrast to the ones in control mice after LPS injection. Additionally, the binding of CLOCK and BMAL1 to StAR’s promoter was elevated after LPS administration, and the binding was higher in \u003ci\u003ePer2\u003c/i\u003e\u003csup\u003em/m\u003c/sup\u003e mice. Furthermore, loss of \u003ci\u003eClock\u003c/i\u003e function resulted in lower survival and failed to induce the serum CORT production and StAR expression in \u003ci\u003eClock\u003csup\u003em/m\u003c/sup\u003e\u003c/i\u003e mice following LPS administration. Our results revealed that CORT, regulated by Bmal1/Clock transcriptional activation of StAR’s expression, could function as a mediator between clock system and immune response and contribute to the endotoxemia resistance in \u003ci\u003ePer2\u003c/i\u003e\u003csup\u003em/m\u003c/sup\u003e mice.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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