{"data":{"id":"10.6084/m9.figshare.c.2112308","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2112308","prefix":"10.6084","suffix":"m9.figshare.c.2112308","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Wang, Huiying","givenName":"Huiying","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Yingnan","givenName":"Yingnan","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Zhao, Qun","givenName":"Qun","familyName":"Zhao","affiliation":[],"nameIdentifiers":[]},{"name":"Guo, Zhanjun","givenName":"Zhanjun","familyName":"Guo","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Huiying","givenName":"Huiying","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Fengbin","givenName":"Fengbin","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Yingnan","givenName":"Yingnan","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Fengbin","givenName":"Fengbin","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Zhao, Yue","givenName":"Yue","familyName":"Zhao","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Ruixing","givenName":"Ruixing","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Ruixing","givenName":"Ruixing","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Identification of sequence polymorphisms in the D-Loop region of mitochondrial DNA as a risk factor for gastric cancer"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Virology"},{"subject":"Infectious Diseases"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cancer"},{"subject":"Mathematics"},{"subject":"FOS: Mathematics","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biological Sciences"},{"subject":"Chemistry"},{"subject":"Earth and Environmental Sciences"},{"subject":"Biotechnology"},{"subject":"Molecular Biology"},{"subject":"Medicine"},{"subject":"Biophysics"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-Loop) of mitochondrial DNA (mtDNA) has been identified for their association with cancer risk in different types of cancers. We investigated the gastric cancer risk profile of D-Loop SNPs in a case-control study. The frequent alleles of nucleotides 73G/A, 235A/G, 309C/C insert, 324C/G, 16,362T/C and 16,519C/T were significantly associated with an increased risk for gastric cancer, whereas the frequent alleles of nucleotides 523–524AC/del were associated with resistance to gastric cancer. In conclusion, SNPs in the mtDNA D-Loop were found to be valuable markers for gastric cancer risk evaluation.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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