{"data":{"id":"10.6084/m9.figshare.c.2111813.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2111813.v1","prefix":"10.6084","suffix":"m9.figshare.c.2111813.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"U. Hawas","affiliation":[],"nameIdentifiers":[]},{"name":"U. Hawas","affiliation":[],"nameIdentifiers":[]},{"name":"S. Eltomy","affiliation":[],"nameIdentifiers":[]},{"name":"S. Eltomy","affiliation":[],"nameIdentifiers":[]},{"name":"R. Nassif","affiliation":[],"nameIdentifiers":[]},{"name":"R. Nassif","affiliation":[],"nameIdentifiers":[]},{"name":"G. El-Hossary","affiliation":[],"nameIdentifiers":[]},{"name":"G. El-Hossary","affiliation":[],"nameIdentifiers":[]},{"name":"S. AbouZid","affiliation":[],"nameIdentifiers":[]},{"name":"S. AbouZid","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"A new antifungal labdane diterpene from the leaves of \u003ci\u003eSaraca indica\u003c/i\u003e"}],"publisher":"Figshare","container":{},"publicationYear":2015,"subjects":[{"subject":"Science Policy"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Ecology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Chemistry"},{"subject":"Earth and Environmental Sciences"},{"subject":"Biotechnology"},{"subject":"Microbiology"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2015-12-05","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/14786419.2013.855931","relatedIdentifierType":"DOI"},{"relationType":"IsPreviousVersionOf","relatedIdentifier":"10.6084/m9.figshare.c.2111813","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"CC-BY","rightsUri":"http://creativecommons.org/licenses/by/3.0/us"}],"descriptions":[{"description":"A new labdane diterpene, along with 10 known sterols and flavonoids, was isolated from the hydroalcoholic extract of the leaves of \u003ci\u003eSaraca indica\u003c/i\u003e. The chemical structure of the new compound was identified as 6,9-epoxy marrubiinic acid on the basis of spectroscopic analyses including two-dimensional NMR. The antimicrobial potential of the new compound was evaluated against Gram-positive and Gram-negative bacteria as well as fungi. It showed a significant antifungal activity against \u003ci\u003eGeotric\u003c/i\u003e\u003ci\u003eh\u003c/i\u003e\u003ci\u003eum candidum\u003c/i\u003e with MIC 0.48 μg/mL. It also showed potential cytotoxicity against human cancer cell lines with IC\u003csub\u003e50\u003c/sub\u003e ranging from 1.07 to 1.29 μg/well.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://figshare.com/collections/A_new_antifungal_labdane_diterpene_from_the_leaves_of_i_Saraca_indica_i_/2111813/1","contentUrl":null,"metadataVersion":3,"schemaVersion":"http://datacite.or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