{"data":{"id":"10.6084/m9.figshare.c.2110778","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2110778","prefix":"10.6084","suffix":"m9.figshare.c.2110778","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Yang, Jingjin","givenName":"Jingjin","familyName":"Yang","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Lijuan","givenName":"Lijuan","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Ting","givenName":"Ting","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Chen, Congcong","givenName":"Congcong","familyName":"Chen","affiliation":[],"nameIdentifiers":[]},{"name":"Han, Lei","givenName":"Lei","familyName":"Han","affiliation":[],"nameIdentifiers":[]},{"name":"Ji, Xiaoming","givenName":"Xiaoming","familyName":"Ji","affiliation":[],"nameIdentifiers":[]},{"name":"Wu, Baiqun","givenName":"Baiqun","familyName":"Wu","affiliation":[],"nameIdentifiers":[]},{"name":"Han, Ruhui","givenName":"Ruhui","familyName":"Han","affiliation":[],"nameIdentifiers":[]},{"name":"Ni, Chunhui","givenName":"Chunhui","familyName":"Ni","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Associations of MMP-7 and OPN gene polymorphisms with risk of coal workers’ pneumoconiosis in a Chinese population: a case-control study"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Biochemistry"},{"subject":"Cell Biology"},{"subject":"Neuroscience"},{"subject":"Physiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biotechnology"},{"subject":"Environmental Sciences not elsewhere classified"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biological Sciences not elsewhere classified"},{"subject":"Cancer"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"\u003ci\u003eBackground\u003c/i\u003e: The matrix metalloproteinase-7 (MMP-7) and osteopontin (OPN) are both multifunctional proteins with roles in inflammation, cell proliferation, tissue remodeling and so on, implicated in the pathogenesis of numerous conditions including pulmonary fibrosis. In this study, we investigated the associations between the potential functional polymorphisms in \u003ci\u003eMMP-7\u003c/i\u003e and \u003ci\u003eOPN\u003c/i\u003e and the risk of coal workers’ pneumoconiosis (CWP) in a Chinese population. \u003ci\u003eMethods\u003c/i\u003e: Four polymorphisms (rs10502001 in \u003ci\u003eMMP-7\u003c/i\u003e, rs1126772, rs11728697 and rs9138 in \u003ci\u003eOPN\u003c/i\u003e) were genotyped and analyzed in a case-control study of 697 CWP and 694 control subjects. \u003ci\u003eResults\u003c/i\u003e: Our results revealed that three single nucleotide polymorphisms (SNPs, \u003ci\u003eMMP-7\u003c/i\u003e rs10502001, \u003ci\u003eOPN\u003c/i\u003e rs1126772 and \u003ci\u003eOPN\u003c/i\u003e rs11728697) were associated with increased risk of CWP under a recessive model (adjusted odds ratio [OR] = 1.80, 95% confidence interval [CI] = 1.01–3.20, \u003ci\u003ep\u003c/i\u003e = 0.045 for \u003ci\u003eMMP-7\u003c/i\u003e rs10502001; adjusted OR = 2.09, 95% CI = 1.17–3.72, \u003ci\u003ep\u003c/i\u003e = 0.013 for \u003ci\u003eOPN\u003c/i\u003e rs1126772; adjusted OR = 2.48, 95% CI = 1.37–4.51, \u003ci\u003ep\u003c/i\u003e = 0.003 for \u003ci\u003eOPN\u003c/i\u003e rs11728697). Additionally, a combined effect was observed in a dose-dependent manner with increasing numbers of risk variant alleles (\u003ci\u003eP\u003c/i\u003e\u003csub\u003etrend\u003c/sub\u003e = 0.003). Furthermore, logistic regression analysis revealed no significant interaction between SNPs and smoking status on CWP risk. \u003ci\u003eConclusions\u003c/i\u003e: Our results indicate that three functional SNPs (\u003ci\u003eMMP-7\u003c/i\u003e rs10502001, \u003ci\u003eOPN\u003c/i\u003e rs11728697 and \u003ci\u003eOPN\u003c/i\u003e rs1126772) are associated with an increased risk of CWP in a Chinese population.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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