{"data":{"id":"10.6084/m9.figshare.c.2110580.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2110580.v1","prefix":"10.6084","suffix":"m9.figshare.c.2110580.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Bækkedal, Cecilie","nameType":"Personal","givenName":"Cecilie","familyName":"Bækkedal","affiliation":[],"nameIdentifiers":[]},{"name":"Peik Haugen","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"The Spot 42 RNA: A regulatory small RNA with roles in the central metabolism"}],"publisher":"Figshare","container":{},"publicationYear":2015,"subjects":[{"subject":"Biophysics"},{"subject":"Biochemistry"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Microbiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"Molecular Biology"},{"subject":"Cancer"},{"subject":"Mental Health"},{"subject":"Hematology"},{"subject":"Infectious Diseases"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Virology"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2016-05-25","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/15476286.2015.1086867","relatedIdentifierType":"DOI"},{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.c.2110580","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"CC-BY","rightsUri":"http://creativecommons.org/licenses/by/3.0/us"}],"descriptions":[{"description":"The Spot 42 RNA is a 109 nucleotide long (in \u003ci\u003eEscherichia coli\u003c/i\u003e) noncoding small regulatory RNA (sRNA) encoded by the \u003ci\u003espf\u003c/i\u003e (spot fourty-two) gene. \u003ci\u003espf\u003c/i\u003e is found in gamma-proteobacteria and the majority of experimental work on Spot 42 RNA has been performed using \u003ci\u003eE. coli,\u003c/i\u003e and recently \u003ci\u003eAliivibrio salmonicida.\u003c/i\u003e In the cell Spot 42 RNA plays essential roles as a regulator in carbohydrate metabolism and uptake, and its expression is activated by glucose, and inhibited by the cAMP-CRP complex. Here we summarize the current knowledge on Spot 42, and present the natural distribution of \u003ci\u003espf\u003c/i\u003e, show family-specific secondary structural features of Spot 42, and link highly conserved structural regions to mRNA target binding.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://figshare.com/collections/The_Spot_42_RNA_A_regulatory_small_RNA_with_roles_in_the_central_metabolism/2110580/1","contentUrl":null,"metadataVersion":3,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2015-12-05T20:35:10.000Z","registered":"2015-12-05T20:35:11.000Z","published":"2015","updated":"2024-12-16T12:36:59.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.c.2110580.v1","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}