{"data":{"id":"10.6084/m9.figshare.c.2110553","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2110553","prefix":"10.6084","suffix":"m9.figshare.c.2110553","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Zhu, Xiao-lu","givenName":"Xiao-lu","familyName":"Zhu","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Juan","givenName":"Juan","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Jiang, Rong-Zhen","givenName":"Rong-Zhen","familyName":"Jiang","affiliation":[],"nameIdentifiers":[]},{"name":"Teng, Yin-Cheng","givenName":"Yin-Cheng","familyName":"Teng","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Pulsatility index in combination with biomarkers or mean arterial pressure for the prediction of pre-eclampsia: Systematic literature review and meta-analysis"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Mathematics"},{"subject":"FOS: Mathematics","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biological Sciences"},{"subject":"Astronomy, Astrophysics, Space Science"},{"subject":"Chemistry"},{"subject":"Earth and Environmental Sciences"},{"subject":"Biophysics"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"\u003ci\u003eIntroduction.\u003c/i\u003e Our objective was to perform a meta-analysis examining the sensitivity of pulsatility index (PI) and various biomarkers and PI and mean arterial pressure (MAP) for the prediction of pre-eclampsia.\u003ci\u003eMaterial and methods.\u003c/i\u003e PubMed, CENTRAL, and Embase databases were searched from inception until 8 May 2014 using combinations of the search terms: pre-eclampsia, ultrasonography, pregnancy, biomarker, mean arterial pressure, placental protein 13, pregnancy-associated plasma protein-A, placental growth factor, activin A, inhibin A, pulsatility index. The pooled sensitivity of PI + biomarkers and PI + MAP were calculated, and reported with corresponding 95% confidence intervals (CIs).\u003ci\u003eResults.\u003c/i\u003e Fifteen studies were included in the meta-analysis. The pooled sensitivity of all biomarkers for the prediction of pre-eclampsia was 0.669 (95% CI 0.610–0.723), for the prediction of early-onset pre-eclampsia was 0.830 (95% CI 0.794–0.861), and for the prediction of late-onset pre-eclampsia was 0.564 (95% CI 0.499–0.627). Similarly, the predictive ability of PI + MAP for early-onset pre-eclampsia was good (sensitivity 0.894), while that for late-onset was poor (sensitivity 0.570).\u003ci\u003eConclusion.\u003c/i\u003e The combination of PI and different biomarkers or MAP exhibits a good predictive ability for early-onset pre-eclampsia, and poor predictive ability for late-onset pre-eclampsia.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/collections/Pulsatility_index_in_combination_with_biomarkers_or_mean_arterial_pressure_for_the_prediction_of_pre_eclampsia_Systematic_literature_review_and_meta_analysis/2110553","conte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