{"data":{"id":"10.6084/m9.figshare.c.2096567.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2096567.v1","prefix":"10.6084","suffix":"m9.figshare.c.2096567.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Chen, Min","givenName":"Min","familyName":"Chen","affiliation":[],"nameIdentifiers":[]},{"name":"Han, Lei","givenName":"Lei","familyName":"Han","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Xiu-Li","givenName":"Xiu-Li","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Chang-Yun","givenName":"Chang-Yun","familyName":"Wang","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Cytotoxic 19-oxygenated steroids from the South China Sea gorgonian, \u003ci\u003ePacifigorgia senta\u003c/i\u003e"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Biochemistry"},{"subject":"Pharmacology"},{"subject":"Environmental Sciences not elsewhere classified"},{"subject":"Chemical Sciences not elsewhere classified"},{"subject":"Ecology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Sociology"},{"subject":"FOS: Sociology","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biological Sciences not elsewhere classified"},{"subject":"Cancer"},{"subject":"Inorganic Chemistry"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Hematology"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.c.2096567","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Bioassay guided chemical investigation of the gorgonian \u003ci\u003ePacifigorgia senta\u003c/i\u003e led to the discovery of a new 19-oxygenated steroid, cholesta-5,24-diene-3\u003ci\u003eβ\u003c/i\u003e,7\u003ci\u003eβ\u003c/i\u003e,19-triol (\u003cb\u003e1\u003c/b\u003e), as well as three known steroids (\u003cb\u003e2\u003c/b\u003e–\u003cb\u003e4\u003c/b\u003e). The structure of \u003cb\u003e1\u003c/b\u003e was determined by extensive spectroscopic analysis, including NMR and MS spectra. All of the compounds exhibited cytotoxicities against HepG2, Hep3B, MCF-7/ADR, PC-3 and HCT-116 cell lines, with the IC\u003csub\u003e50\u003c/sub\u003e values ranging from 7.0 to 29.7 μM. It is the first report on the chemical constituents of the coral species \u003ci\u003eP. senta\u003c/i\u003e.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"PD94bWwgdmVyc2lvbj0iMS4wIiBlbmNvZGluZz0iVVRGLTgiPz4KPHJlc291cmNlIHhtbG5zPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCIgeG1sbnM6eHNpPSJodHRwOi8vd3d3LnczLm9yZy8yMDAxL1hNTFNjaGVtYS1pbnN0YW5jZSIgeHNpOnNjaGVtYUxvY2F0aW9uPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCBodHRwOi8vc2NoZW1hLmRhdGFjaXRlLm9yZy9tZXRhL2tlcm5lbC00LjQvbWV0YWRhdGEueHNkIj4KICA8aWRlbnRpZmllciBpZGVudGlmaWVyVHlwZT0iRE9JIj4xMC42MDg0L005LkZJR1NIQVJFLkMuMjA5NjU2Ny5WMTwvaWRlbnRpZmllcj4KICA8Y3JlYXRvcnM+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPk1pbiBDaGVuPC9jcmVhdG9yTmFtZT4KICAgICAgPGdpdmVuTmFtZT5NaW48L2dpdmVuTmFtZT4KICAgICAgPGZhbWlseU5hbWU+Q2hlbjwvZmFtaWx5TmFtZT4KICAgIDwvY3JlYXRvcj4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+TGVpIEhhbjwvY3JlYXRvck5hbWU+CiAgICAgIDxnaXZlbk5hbWU+TGVpPC9naXZlbk5hbWU+CiAgICAgIDxmYW1pbHlOYW1lPkhhbjwvZmFtaWx5TmFtZT4KICAgIDwvY3JlYXRvcj4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+WGl1LUxpIFpoYW5nPC9jcmVhdG9yTmFtZT4KICAgICAgPGdpdmVuTmFtZT5YaXUtTGk8L2dpdmVuTmFtZT4KICAgICAgPGZhbWlseU5hbWU+Wmhhbmc8L2ZhbWlseU5hbWU+CiAgICA8L2NyZWF0b3I+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPkNoYW5nLVl1biBXYW5nPC9jcmVhdG9yTmFtZT4KICAgICAgPGdpdmVuTmFtZT5DaGFuZy1ZdW48L2dpdmVuTmFtZT4KICAgICAgPGZhbWlseU5hbWU+V2FuZzwvZmFtaWx5TmFtZT4KICAgIDwvY3JlYXRvcj4KICA8L2NyZWF0b3JzPgogIDx0aXRsZXM+CiAgICA8dGl0bGU+Q3l0b3RveGljIDE5LW94eWdlbmF0ZWQgc3Rlcm9pZHMgZnJvbSB0aGUgU291dGggQ2hpbmEgU2VhIGdvcmdvbmlhbiwgJmx0O2kmZ3Q7UGFjaWZpZ29yZ2lhIHNlbnRhJmx0Oy9pJmd0OzwvdGl0bGU+CiAgPC90aXRsZXM+CiAgPGRlc2NyaXB0aW9ucz4KICAgIDxkZXNjcmlwdGlvbiBkZXNjcmlwdGlvblR5cGU9IkFic3RyYWN0Ij4mbHQ7cCZndDtCaW9hc3NheSBndWlkZWQgY2hlbWljYWwgaW52ZXN0aWdhdGlvbiBvZiB0aGUgZ29yZ29uaWFuICZsdDtpJmd0O1BhY2lmaWdvcmdpYSBzZW50YSZsdDsvaSZndDsgbGVkIHRvIHRoZSBkaXNjb3Zlcnkgb2YgYSBuZXcgMTktb3h5Z2VuYXRlZCBzdGVyb2lkLCBjaG9sZXN0YS01LDI0LWRpZW5lLTMmbHQ7aSZndDvOsiZsdDsvaSZndDssNyZsdDtpJmd0O86yJmx0Oy9pJmd0OywxOS10cmlvbCAoJmx0O2ImZ3Q7MSZsdDsvYiZndDspLCBhcyB3ZWxsIGFzIHRocmVlIGtub3duIHN0ZXJvaWRzICgmbHQ7YiZndDsyJmx0Oy9iJmd0O+KAkyZsdDtiJmd0OzQmbHQ7L2ImZ3Q7KS4gVGhlIHN0cnVjdHVyZSBvZiAmbHQ7YiZndDsxJmx0Oy9iJmd0OyB3YXMgZGV0ZXJtaW5lZCBieSBleHRlbnNpdmUgc3BlY3Ryb3Njb3BpYyBhbmFseXNpcywgaW5jbHVkaW5nIE5NUiBhbmQgTVMgc3BlY3RyYS4gQWxsIG9mIHRoZSBjb21wb3VuZHMgZXhoaWJpdGVkIGN5dG90b3hpY2l0aWVzIGFnYWluc3QgSGVwRzIsIEhlcDNCLCBNQ0YtNy9BRFIsIFBDLTMgYW5kIEhDVC0xMTYgY2VsbCBsaW5lcywgd2l0aCB0aGUgSUMmbHQ7c3ViJmd0OzUwJmx0Oy9zdWImZ3Q7IHZhbHVlcyByYW5naW5nIGZyb20gNy4wIHRvIDI5LjfCoM68TS4gSXQgaXMgdGhlIGZpcnN0IHJlcG9ydCBvbiB0aGUgY2hlbWljYWwgY29uc3RpdHVlbnRzIG9mIHRoZSBjb3JhbCBzcGVjaWVzICZsdDtpJmd0O1AuIHNlbnRhJmx0Oy9pJmd0Oy4mbHQ7L3AmZ3Q7PC9kZXNjcmlwdGlvbj4KICA8L2Rlc2NyaXB0aW9ucz4KICA8c3ViamVjdHM+CiAgICA8c3ViamVjdD5CaW9jaGVtaXN0cnk8L3N1YmplY3Q+CiAgICA8c3ViamVjdD5QaGFybWFjb2xvZ3k8L3N1YmplY3Q+CiAgICA8c3ViamVjdD5FbnZpcm9ubWVudGFsIFNjaWVuY2VzIG5vdCBlbHNld2hlcmUgY2xhc3NpZmllZDwvc3ViamVjdD4KICAgIDxzdWJqZWN0PkNoZW1pY2FsIFNjaWVuY2VzIG5vdCBlbHNld2hlcmUgY2xhc3NpZmllZDwvc3ViamVjdD4KICAgIDxzdWJqZWN0PkVjb2xvZ3k8L3N1YmplY3Q+CiAgICA8c3ViamVjdD5Tb2Npb2xvZ3k8L3N1YmplY3Q+CiAgICA8c3ViamVjdD5CaW9sb2dpY2FsIFNjaWVuY2VzIG5vdCBlbHNld2hlcmUgY2xhc3NpZmllZDwvc3ViamVjdD4KICAgIDxzdWJqZWN0PkNhbmNlcjwvc3ViamVjdD4KICAgIDxzdWJqZWN0Pklub3JnYW5pYyBDaGVtaXN0cnk8L3N1YmplY3Q+CiAgICA8c3ViamVjdD5IZW1hdG9sb2d5PC9zdWJqZWN0PgogIDwvc3ViamVjdHM+CiAgPHB1Ymxpc2hlcj5UYXlsb3IgJmFtcDsgRnJhbmNpczwvcHVibGlzaGVyPgogIDxwdWJsaWNhdGlvblllYXI+MjAxNTwvcHVibGljYXRpb25ZZWFyPgogIDxkYXRlcz4KICAgIDxkYXRlIGRhdGVUeXBlPSJDcmVhdGVkIj4yMDE1LTEyLTA1PC9kYXRlPgogICAgPGRhdGUgZGF0ZVR5cGU9IlVwZGF0ZWQiPjIwMTktMDgtMTk8L2RhdGU+CiAgPC9kYXRlcz4KICA8cmVzb3VyY2VUeXBlIHJlc291cmNlVHlwZUdlbmVyYWw9IkNvbGxlY3Rpb24iPkNvbGxlY3Rpb248L3Jlc291cmNlVHlwZT4KICA8cmVsYXRlZElkZW50aWZpZXJzPgogICAgPHJlbGF0ZWRJZGVudGlmaWVyIHJlbGF0ZWRJZGVudGlmaWVyVHlwZT0iRE9JIiByZWxhdGlvblR5cGU9IklzSWRlbnRpY2FsVG8iPjEwLjYwODQvbTkuZmlnc2hhcmUuYy4yMDk2NTY3PC9yZWxhdGVkSWRlbnRpZmllcj4KICA8L3JlbGF0ZWRJZGVudGlmaWVycz4KICA8cmlnaHRzTGlzdD4KICAgIDxyaWdodHMgcmlnaHRzVVJJPSJodHRwczovL2NyZWF0aXZlY29tbW9ucy5vcmcvbGljZW5zZXMvYnkvNC4wLyI+Q0MgQlkgNC4wPC9yaWdodHM+CiAgPC9yaWdodHNMaXN0Pgo8L3Jlc291cmNlPg==","url":"https://tandf.figshare.com/collections/Cytotoxic_19_oxygenated_steroids_from_the_South_China_Sea_gorgonian_i_Pacifigorgia_senta_i_/2096567/1","contentUrl":null,"metadataVersion":3,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2015-12-05T20:31:54.000Z","registered":"2015-12-05T20:31:55.000Z","published":"2015","updated":"2024-03-21T09:20:34.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.c.2096567.v1","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":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