{"data":{"id":"10.6084/m9.figshare.c.2093597","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2093597","prefix":"10.6084","suffix":"m9.figshare.c.2093597","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Xuan, Bixia","givenName":"Bixia","familyName":"Xuan","affiliation":[],"nameIdentifiers":[]},{"name":"Du, Xing","givenName":"Xing","familyName":"Du","affiliation":[],"nameIdentifiers":[]},{"name":"Li, Xiaoping","givenName":"Xiaoping","familyName":"Li","affiliation":[],"nameIdentifiers":[]},{"name":"Shen, Zhengwu","givenName":"Zhengwu","familyName":"Shen","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"A new potent immunosuppressive isoflavanonol from \u003ci\u003eCampylotropis hirtella\u003c/i\u003e"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Biochemistry"},{"subject":"Space Science"},{"subject":"Cell Biology"},{"subject":"Pharmacology"},{"subject":"Evolutionary Biology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Environmental Sciences not elsewhere classified"},{"subject":"Chemical Sciences not elsewhere classified"},{"subject":"Ecology"},{"subject":"Sociology"},{"subject":"FOS: Sociology","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biological Sciences not elsewhere classified"},{"subject":"Infectious Diseases"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Four new flavonoids were isolated from \u003ci\u003eCampylotropis hirtella\u003c/i\u003e and these are a chromone and a 2H-chromene, an isoflavone and an isoflavanonol. The structures of these compounds were elucidated by extensive spectroscopic measurements. All of the compounds were assessed for immunosuppressive activity. Compound \u003cb\u003e4\u003c/b\u003e showed very strong T lymphocyte suppression activity (IC\u003csub\u003e50\u003c/sub\u003e: 0.13 μM) and potent B lymphocyte suppression activity (IC\u003csub\u003e50\u003c/sub\u003e: 0.26 μM). Due to its potent immunosuppressive activity and lower cytotoxicity, further structure–activity studies will be pursued on this compound.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/collections/A_new_potent_immunosuppressive_isoflavanonol_from_i_Campylotropis_hirtella_i_/2093597","contentUrl":null,"metadataVersion":3,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2015-12-05T18:08:36.000Z","registered":"2015-12-05T18:08:37.000Z","published":"2015","updated":"2024-03-21T09:20:25.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.c.2093597","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}