{"data":{"id":"10.6084/m9.figshare.c.2093549","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2093549","prefix":"10.6084","suffix":"m9.figshare.c.2093549","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Sansone, Francesca","nameType":"Personal","givenName":"Francesca","familyName":"Sansone","affiliation":[],"nameIdentifiers":[]},{"name":"Esposito, Tiziana","nameType":"Personal","givenName":"Tiziana","familyName":"Esposito","affiliation":[],"nameIdentifiers":[]},{"name":"Mencherini, Teresa","nameType":"Personal","givenName":"Teresa","familyName":"Mencherini","affiliation":[],"nameIdentifiers":[]},{"name":"Piccinelli, Anna Lisa","nameType":"Personal","givenName":"Anna Lisa","familyName":"Piccinelli","affiliation":[],"nameIdentifiers":[]},{"name":"Gazzerro, Patrizia","nameType":"Personal","givenName":"Patrizia","familyName":"Gazzerro","affiliation":[],"nameIdentifiers":[]},{"name":"Picerno, Patrizia","nameType":"Personal","givenName":"Patrizia","familyName":"Picerno","affiliation":[],"nameIdentifiers":[]},{"name":"Russo, Paola","nameType":"Personal","givenName":"Paola","familyName":"Russo","affiliation":[],"nameIdentifiers":[]},{"name":"Gaudio, Pasquale Del","nameType":"Personal","givenName":"Pasquale Del","familyName":"Gaudio","affiliation":[],"nameIdentifiers":[]},{"name":"Massimilano Essolito","affiliation":[],"nameIdentifiers":[]},{"name":"Campiglia, Pietro","nameType":"Personal","givenName":"Pietro","familyName":"Campiglia","affiliation":[],"nameIdentifiers":[]},{"name":"Aquino, Rita P.","nameType":"Personal","givenName":"Rita P.","familyName":"Aquino","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Annurca peel extract: from the chemical composition, through the functional activity, to the formulation and characterisation of a topical oil-in-water emulsion"}],"publisher":"Figshare","container":{},"publicationYear":2015,"subjects":[{"subject":"Biochemistry"},{"subject":"Cell Biology"},{"subject":"Biotechnology"},{"subject":"59999 Environmental Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Earth and related environmental sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Earth and related environmental sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Sociology"},{"subject":"FOS: Sociology","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Sociology","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Developmental Biology"},{"subject":"Plant Biology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2016-05-20","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/14786419.2015.1062005","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"CC-BY","rightsUri":"http://creativecommons.org/licenses/by/3.0/us"}],"descriptions":[{"description":"The aim of this study was to produce a hydro-alcoholic safe antioxidant \u003ci\u003eMalus pumila\u003c/i\u003e Miller cv Annurca peel extract (APE) useful as functional ingredient in an oil-in-water emulsion. Results showed that APE contains a hydroxycinnamic acid (chlorogenic acid), flavonol glycosides (quercetin derivatives) and a dihydrochalcone, phloridzin (phloretin-2-\u003ci\u003eO\u003c/i\u003e-glucoside). The isoquercitrin (quercetin-3-\u003ci\u003eO\u003c/i\u003e-glucoside) content was quantified in 0.3% w/w of extract. APE showed a significant and concentration-dependent free-radical scavenging activity correlated to its polyphenols content. No cytotoxic effect was observed in primary human epidermal keratinocyte adults and dermal fibroblast cell lines. The formulative approach led to produce a stable emulsion able to load a high amount of APE, up to 6.0% w/w. The homogenous distribution of APE in the emulsion was clearly demonstrated by fluorescence microscopy analysis. The emulsion resulted able to enhance the \u003ci\u003ein vitro\u003c/i\u003e release rate of APE through synthetic membranes with respect to the raw material.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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