{"data":{"id":"10.6084/m9.figshare.c.2092109.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2092109.v1","prefix":"10.6084","suffix":"m9.figshare.c.2092109.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Charneau, Sébastien","nameType":"Personal","givenName":"Sébastien","familyName":"Charneau","affiliation":[],"nameIdentifiers":[]},{"name":"Mesquita, Mariana Laundry De","nameType":"Personal","givenName":"Mariana Laundry De","familyName":"Mesquita","affiliation":[],"nameIdentifiers":[]},{"name":"Bastos, Izabela Marques Dourado","nameType":"Personal","givenName":"Izabela Marques Dourado","familyName":"Bastos","affiliation":[],"nameIdentifiers":[]},{"name":"Santana, Jaime Martins","nameType":"Personal","givenName":"Jaime Martins","familyName":"Santana","affiliation":[],"nameIdentifiers":[]},{"name":"Paula, José Elias De","nameType":"Personal","givenName":"José Elias De","familyName":"Paula","affiliation":[],"nameIdentifiers":[]},{"name":"Grellier, Philippe","nameType":"Personal","givenName":"Philippe","familyName":"Grellier","affiliation":[],"nameIdentifiers":[]},{"name":"Espindola, Laila Salmen","nameType":"Personal","givenName":"Laila Salmen","familyName":"Espindola","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"\u003ci\u003eIn vitro\u003c/i\u003e investigation of Brazilian Cerrado plant extract activity against \u003ci\u003ePlasmodium falciparum\u003c/i\u003e, \u003ci\u003eTrypanosoma cruzi\u003c/i\u003e and \u003ci\u003eT. brucei gambiense\u003c/i\u003e"}],"publisher":"Figshare","container":{},"publicationYear":2015,"subjects":[{"subject":"Biochemistry"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Medicine"},{"subject":"Microbiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"59999 Environmental Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Earth and related environmental sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Earth and related environmental sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Ecology"},{"subject":"69999 Biological Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"Plant Biology"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2016-05-20","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/14786419.2015.1055264","relatedIdentifierType":"DOI"},{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.c.2092109","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"CC-BY","rightsUri":"http://creativecommons.org/licenses/by/3.0/us"}],"descriptions":[{"description":"The threatened Brazilian Cerrado biome is an important biodiversity hotspot but still few explored that constitutes a potential reservoir of molecules to treat infectious diseases. We selected eight Cerrado plant species for screening against the erythrocytic stages of \u003ci\u003ePlasmodium falciparum\u003c/i\u003e, human intracellular stages of \u003ci\u003eTrypanosoma cruzi\u003c/i\u003e and bloodstream forms of \u003ci\u003eT. brucei gambiense\u003c/i\u003e, and for their cytotoxicity upon the rat L6-myoblast cell line. Bioassays were performed with 37 hexane, ethyl acetate and ethanol extracts prepared from different plant organs. Activities against parasites were observed for 24 extracts: 9 with anti-\u003ci\u003eP. falciparum\u003c/i\u003e, 4 with anti-\u003ci\u003eT. cruzi\u003c/i\u003e and 11 with anti-\u003ci\u003eT. brucei gambiense\u003c/i\u003e activities. High anti-protozoal activity (IC\u003csub\u003e50\u003c/sub\u003e values Connarus suberosus, \u003ci\u003eBlepharocalyx salicifolius\u003c/i\u003e, \u003ci\u003ePsidium laruotteanum\u003c/i\u003e and \u003ci\u003eMyrsine guianensis\u003c/i\u003e. Overall, studies of plant extracts will contribute to increase the biodiversity knowledge essential for Cerrado conservation and sustainable development.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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