{"data":{"id":"10.6084/m9.figshare.c.2089106","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2089106","prefix":"10.6084","suffix":"m9.figshare.c.2089106","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Han, Lu","givenName":"Lu","familyName":"Han","affiliation":[],"nameIdentifiers":[]},{"name":"Ma, Yang-Mei","givenName":"Yang-Mei","familyName":"Ma","affiliation":[],"nameIdentifiers":[]},{"name":"An, Li","givenName":"Li","familyName":"An","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Qiao","givenName":"Qiao","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Chang-Li","givenName":"Chang-Li","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Zhao, Qing-Chun","givenName":"Qing-Chun","familyName":"Zhao","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Non-alkaloids extract from \u003ci\u003eStemona sessilifolia\u003c/i\u003e enhances the activity of chemotherapeutic agents through P-glycoprotein-mediated multidrug-resistant cancer cells"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Biochemistry"},{"subject":"Cell Biology"},{"subject":"Pharmacology"},{"subject":"Biotechnology"},{"subject":"Chemical Sciences not elsewhere classified"},{"subject":"Cancer"},{"subject":"Hematology"},{"subject":"Infectious Diseases"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Virology"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"One of the major impediments to the successful treatment of cancer is the development of resistant cancer cells, which could cause multidrug resistance (MDR), and overexpression of ABCB1/P-glycoprotein (P-gp) is one of the most common causes of MDR in cancer cells. Recently, natural products or plant-derived chemicals have been investigated more and more widely as potential multidrug-resistant (MDR) reversing agents. The current study demonstrated for the first time that non-alkaloids extract from \u003ci\u003eStemona sessilifolia\u003c/i\u003e significantly reversed the resistance of chemotherapeutic agents, adriamycin, paclitaxel and vincristine to MCF-7/ADR cells compared with MCF-7/S cells in a dose-dependent manner. The results obtained from these studies indicated that the non-alkaloids extract from \u003ci\u003eS. sessilifolia\u003c/i\u003e plays an important role in reversing MDR of cancer as a P-gp modulator \u003ci\u003ein vitro\u003c/i\u003e and may be effective in the treatment of multidrug-resistant cancers.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/collections/Non_alkaloids_extract_from_i_Stemona_sessilifolia_i_enhances_the_activity_of_chemotherapeutic_agents_through_P_glycoprotein_mediated_multidrug_resistant_cancer_cells/2089106","contentUrl":null,"metadataVersion":3,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount"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