{"data":{"id":"10.6084/m9.figshare.c.2086595","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2086595","prefix":"10.6084","suffix":"m9.figshare.c.2086595","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Barreto, Humberto M.","nameType":"Personal","givenName":"Humberto M.","familyName":"Barreto","affiliation":[],"nameIdentifiers":[]},{"name":"Kivia M.R.N. Coelho","affiliation":[],"nameIdentifiers":[]},{"name":"Ferreira, Josie H.L.","nameType":"Personal","givenName":"Josie H.L.","familyName":"Ferreira","affiliation":[],"nameIdentifiers":[]},{"name":"Santos, Bernadete H.C. Dos","nameType":"Personal","givenName":"Bernadete H.C. Dos","familyName":"Santos","affiliation":[],"nameIdentifiers":[]},{"name":"Aislan P.L. De Abreu","affiliation":[],"nameIdentifiers":[]},{"name":"Coutinho, Henrique D.M.","nameType":"Personal","givenName":"Henrique D.M.","familyName":"Coutinho","affiliation":[],"nameIdentifiers":[]},{"name":"Romezio A.C. Da Silva","affiliation":[],"nameIdentifiers":[]},{"name":"Taciana O. De Sousa","affiliation":[],"nameIdentifiers":[]},{"name":"Citó, Antonia M. Das G.L.","nameType":"Personal","givenName":"Antonia M. Das G.L.","familyName":"Citó","affiliation":[],"nameIdentifiers":[]},{"name":"Lopes, José A.D.","nameType":"Personal","givenName":"José A.D.","familyName":"Lopes","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Enhancement of the antibiotic activity of aminoglycosides by extracts from \u003ci\u003eAnadenanthera colubrine\u003c/i\u003e (Vell.) Brenan var. \u003ci\u003ecebil\u003c/i\u003e against multi-drug resistant bacteria"}],"publisher":"Figshare","container":{},"publicationYear":2015,"subjects":[{"subject":"Biochemistry"},{"subject":"Medicine"},{"subject":"Microbiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Pharmacology"},{"subject":"Biotechnology"},{"subject":"59999 Environmental Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Earth and related environmental sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Earth and related environmental sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Ecology"},{"subject":"Sociology"},{"subject":"FOS: Sociology","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Sociology","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Infectious Diseases"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2016-05-20","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/14786419.2015.1049177","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"CC-BY","rightsUri":"http://creativecommons.org/licenses/by/3.0/us"}],"descriptions":[{"description":"The aim of this work was to evaluate the antimicrobial activity of ethanol (EEAC) and hexane (HFAC) extracts from the stem bark of \u003ci\u003eAnadenanthera colubrina\u003c/i\u003e (Vell.) Brenan var. \u003ci\u003ecebil\u003c/i\u003e alone or in combination with aminoglycosides against multi-drug resistant (MDR) bacteria. Minimal inhibitory concentrations (MICs) of the extracts were determined by using microdilution assay. For the evaluation of extracts as modulators of antibiotic resistance, MICs of neomycin and amikacin were determined in presence or absence of each compound at sub-inhibitory concentrations. Both EEAC and HFAC did not show antimicrobial activity against MDR strains tested. However, the addition of EEAC and HFAC enhanced the activity of neomycin and amikacin against \u003ci\u003eStaphylococcus aureus\u003c/i\u003e SA10 strain. When the natural products were replaced by chlorpromazine, the same effect was observed. \u003ci\u003eAnadenanthera colubrine\u003c/i\u003e var. \u003ci\u003ecebil\u003c/i\u003e may be a source of phytochemicals able to potentiate the aminoglycoside activity against MDR \u003ci\u003eS. aureus\u003c/i\u003e by the inhibition of efflux pump.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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