{"data":{"id":"10.6084/m9.figshare.c.2085029","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2085029","prefix":"10.6084","suffix":"m9.figshare.c.2085029","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Parlapally, Sunitha","nameType":"Personal","givenName":"Sunitha","familyName":"Parlapally","affiliation":[],"nameIdentifiers":[]},{"name":"Neeraja Cherukupalli","affiliation":[],"nameIdentifiers":[]},{"name":"Sudarshana Reddy Bhumireddy","affiliation":[],"nameIdentifiers":[]},{"name":"Prabhakar Sripadi","affiliation":[],"nameIdentifiers":[]},{"name":"Ravindernath Anisetti","affiliation":[],"nameIdentifiers":[]},{"name":"Giri, Charu Chandra","nameType":"Personal","givenName":"Charu Chandra","familyName":"Giri","affiliation":[],"nameIdentifiers":[]},{"name":"Venkateswara Rao Khareedu","affiliation":[],"nameIdentifiers":[]},{"name":"Dashavantha Reddy Vudem","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Chemical profiling and anti-psoriatic activity of methanolic extract of \u003ci\u003eAndrographis nallamalayana\u003c/i\u003e J.L.Ellis"}],"publisher":"Figshare","container":{},"publicationYear":2015,"subjects":[{"subject":"Biochemistry"},{"subject":"Medicine"},{"subject":"Pharmacology"},{"subject":"59999 Environmental Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Earth and related environmental sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Earth and related environmental sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Ecology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"69999 Biological Sciences not elsewhere classified","subjectScheme":"FOR"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2016-05-20","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/14786419.2015.1054825","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"CC-BY","rightsUri":"http://creativecommons.org/licenses/by/3.0/us"}],"descriptions":[{"description":"\u003ci\u003eAndrographis nallamalayana\u003c/i\u003e is being widely used as tribal medicine in the treatment of leucoderma and mouth ulcers. Chemical profiling of methanolic extract of the whole plant (PE), using GC–MS and LC–MS, revealed the presence of compounds viz. α-tocopherol, β-sitosterol, tetradecanoic acid, monostearin, flavones/flavanones and their glycosides, chromones, etc. Topical application of imiquimod on the dorsal portion of male BALB/C mice resulted in the development of psoriatic symptoms (erythema, scaling, thickening and folding) with a mean disease activity index (DAI) of \u0026gt;7.0. Topical treatment with 100-μL PE (~6.4%\u003cb\u003e/\u003c/b\u003e12.8%) formulations, for 12-days, resulted in the alleviation of disease symptoms. Compared to water-based formulations, emu oil-based formulation, PE400EO was found more effective in reducing the mean DAI (\u0026gt;84%), keratinocyte count (\u0026gt;65%) (\u003ci\u003ep\u003c/i\u003e p A. nallamalayana having great potential in developing a potent phytomedicine against psoriasis.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://figshare.com/collections/Chemical_profiling_and_anti_psoriatic_activity_of_methanolic_extract_of_i_Andrographis_nallamalayana_i_J_L_Ellis/2085029","contentUrl":null,"metadataVersion":3,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2015-12-05T17:59:11.000Z","registered":"2015-12-05T17:59:12.000Z","published":"2015","updated":"2024-12-12T14:35:13.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.c.2085029","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}