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    <title>The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux</title>
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    <description descriptionType="Abstract">&lt;div&gt;&lt;p&gt;Oncogenic mutation of KRAS (Kirsten rat sarcoma viral oncogene homolog) in colorectal cancer (CRC) confers resistance to both chemotherapy and EGFR (epidermal growth factor receptor)-targeted therapy. We uncovered that KRAS mutant (KRAS&lt;sup&gt;mut&lt;/sup&gt;) CRC is uniquely sensitive to treatment with recombinant LGALS9/Galectin-9 (rLGALS9), a recently established regulator of epithelial polarity. Upon treatment of CRC cells, rLGALS9 rapidly internalizes via early- and late-endosomes and accumulates in the lysosomal compartment. Treatment with rLGALS9 is accompanied by induction of frustrated autophagy in KRAS&lt;sup&gt;mut&lt;/sup&gt; CRC, but not in CRC with BRAF (B-Raf proto-oncogene, serine/threonine kinase) mutations (BRAF&lt;sup&gt;mut&lt;/sup&gt;). In KRAS&lt;sup&gt;mut&lt;/sup&gt; CRC, rLGALS9 acts as a lysosomal inhibitor that inhibits autophagosome-lysosome fusion, leading to autophagosome accumulation, excessive lysosomal swelling and cell death. This antitumor activity of rLGALS9 directly correlates with elevated basal autophagic flux in KRAS&lt;sup&gt;mut&lt;/sup&gt; cancer cells. Thus, rLGALS9 has potent antitumor activity toward refractory KRAS&lt;sup&gt;mut&lt;/sup&gt; CRC cells that may be exploitable for therapeutic use.&lt;/p&gt;&lt;/div&gt;</description>
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