{"data":{"id":"10.6084/m9.figshare.c.2068988","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2068988","prefix":"10.6084","suffix":"m9.figshare.c.2068988","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Liu, Bing","givenName":"Bing","familyName":"Liu","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Hai-Feng","givenName":"Hai-Feng","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Li-hua","givenName":"Li-hua","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Liu, Fang","givenName":"Fang","familyName":"Liu","affiliation":[],"nameIdentifiers":[]},{"name":"He, Feng-Jun","givenName":"Feng-Jun","familyName":"He","affiliation":[],"nameIdentifiers":[]},{"name":"Bai, Jiao","givenName":"Jiao","familyName":"Bai","affiliation":[],"nameIdentifiers":[]},{"name":"Hua, Hui-Ming","givenName":"Hui-Ming","familyName":"Hua","affiliation":[],"nameIdentifiers":[]},{"name":"Chen, Gang","givenName":"Gang","familyName":"Chen","affiliation":[],"nameIdentifiers":[]},{"name":"Pei, Yue-Hu","givenName":"Yue-Hu","familyName":"Pei","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"New compound with DNA Topo I inhibitory activity purified from \u003ci\u003ePenicillium oxalicum\u003c/i\u003e HSY05"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Biological Sciences"},{"subject":"Sociology"},{"subject":"FOS: Sociology","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Chemistry"},{"subject":"Earth and Environmental Sciences"},{"subject":"Pharmacology"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Strain HSY05 was isolated from sea sediment collected from the South China Sea and was later identified as \u003ci\u003ePenicillium oxalicum\u003c/i\u003e by 16S rDNA sequence analysis. Various chromatographic processes led to the isolation and purification of two metabolites from the fermentation culture of HSY05, including one new compound, 2,2′,4,4′-tetrahyoxy-8′-methyl-6-methoxy-acyl-ethyl-diphenylmethanone (\u003cb\u003e1\u003c/b\u003e), and a known compound secalonic acid D (SAD, \u003cb\u003e2\u003c/b\u003e), as characterised by UV, IR, 1D, 2D-NMR and MS data. The inhibitory activities against topoisomerase I of these two compounds were evaluated. The result showed that in addition to the known topo I inhibitor SAD (\u003cb\u003e2\u003c/b\u003e), compound \u003cb\u003e1\u003c/b\u003e also exhibited a moderate inhibitory effect.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/collections/New_compound_with_DNA_Topo_I_inhibitory_activity_purified_from_i_Penicillium_oxalicum_i_HSY05/2068988","contentUrl":null,"metadataVersion":2,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverT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