{"data":{"id":"10.6084/m9.figshare.c.2062673","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2062673","prefix":"10.6084","suffix":"m9.figshare.c.2062673","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Shi, Kai","givenName":"Kai","familyName":"Shi","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, XuLei","givenName":"XuLei","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Zhu, Jie","givenName":"Jie","familyName":"Zhu","affiliation":[],"nameIdentifiers":[]},{"name":"Cao, GuiQun","givenName":"GuiQun","familyName":"Cao","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Kang","givenName":"Kang","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Su, Zhiguang","givenName":"Zhiguang","familyName":"Su","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Salidroside protects retinal endothelial cells against hydrogen peroxide-induced injury via modulating oxidative status and apoptosis"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Cancer"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Chemistry"},{"subject":"Physiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"Cell Biology"},{"subject":"Microbiology"},{"subject":"Medicine"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Oxidative stress can cause injury in retinal endothelial cells. Salidroside is a strong antioxidative and cytoprotective supplement in Chinese traditional medicine. In this study, we investigated the effects of salidroside on H\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e2\u003c/sub\u003e-induced primary retinal endothelial cells injury. Salidroside decreased H\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e2\u003c/sub\u003e-induced cell death, and efficiently suppressed cellular ROS production, malondialdehyde generation, and cell apoptosis induced by H\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e2\u003c/sub\u003e treatment. Salidroside induced the intracellular mRNA expression, protein expression, and enzymatic activities of catalase and Mn-SOD and increased the ratio of Bcl2/Bax. Our results demonstrated that salidroside protected retinal endothelial cells against oxidative injury through increasing the Bcl2/Bax signaling pathway and activation of endogenous antioxidant enzymes. This finding presents salidroside as an attractive agent with potential to attenuate retinopathic diseases.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/collections/Salidroside_protects_retinal_endothelial_cells_against_hydrogen_peroxide_induced_injury_via_modulating_oxidative_status_and_apoptosis/2062673","contentUrl":null,"metadataVersion":2,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citat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