{"data":{"id":"10.6084/m9.figshare.c.2061125.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2061125.v1","prefix":"10.6084","suffix":"m9.figshare.c.2061125.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Zhou, Xiang","givenName":"Xiang","familyName":"Zhou","affiliation":[],"nameIdentifiers":[]},{"name":"Fang, Pingyan","givenName":"Pingyan","familyName":"Fang","affiliation":[],"nameIdentifiers":[]},{"name":"Li, Xiaofan","givenName":"Xiaofan","familyName":"Li","affiliation":[],"nameIdentifiers":[]},{"name":"Li, Shuiming","givenName":"Shuiming","familyName":"Li","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Yong","givenName":"Yong","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Liu, Gang","givenName":"Gang","familyName":"Liu","affiliation":[],"nameIdentifiers":[]},{"name":"He, Zhendan","givenName":"Zhendan","familyName":"He","affiliation":[],"nameIdentifiers":[]},{"name":"Gou, Deming","givenName":"Deming","familyName":"Gou","affiliation":[],"nameIdentifiers":[]},{"name":"Yao, Xinsheng","givenName":"Xinsheng","familyName":"Yao","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Liyan","givenName":"Liyan","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Tang, Jianqiang","givenName":"Jianqiang","familyName":"Tang","affiliation":[],"nameIdentifiers":[]},{"name":"Wu, Zhiqin","givenName":"Zhiqin","familyName":"Wu","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"A novel cyclic dipeptide from deep marine-derived fungus \u003ci\u003eAspergillus\u003c/i\u003e sp. SCSIOW2"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Hematology"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Chemistry"},{"subject":"Earth and Environmental Sciences"},{"subject":"Microbiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.c.2061125","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"A novel cyclic dipeptide, 14-hydroxy-cyclopeptine (\u003cb\u003e1\u003c/b\u003e), was purified from a deep sea derived fungal isolate identified as an \u003ci\u003eAspergillus\u003c/i\u003e sp. The structure was elucidated by detailed spectroscopic analyses using 1D and 2D NMR experiments and high resolution mass spectrometry. The absolute configuration of the amino acid was determined by Marfey's method. Two conformational isomers of \u003cb\u003e1\u003c/b\u003e were established by ROE analyses. \u003cb\u003e1\u003c/b\u003e inhibited nitric oxide production with IC\u003csub\u003e50\u003c/sub\u003e values at 40.3 μg/mL in a lipopolysaccharide and recombinant mouse interferon-γ -activated macrophage-like cell line, RAW 264.7 and showed no cytotoxic effect in the tested dose range up to 100 μg/mL.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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