{"data":{"id":"10.6084/m9.figshare.c.2047307.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2047307.v1","prefix":"10.6084","suffix":"m9.figshare.c.2047307.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Guo, Qingfeng","givenName":"Qingfeng","familyName":"Guo","affiliation":[],"nameIdentifiers":[]},{"name":"Dong, Lili","givenName":"Lili","familyName":"Dong","affiliation":[],"nameIdentifiers":[]},{"name":"Zang, Xiangyun","givenName":"Xiangyun","familyName":"Zang","affiliation":[],"nameIdentifiers":[]},{"name":"Gu, Zijian","givenName":"Zijian","familyName":"Gu","affiliation":[],"nameIdentifiers":[]},{"name":"He, Xiaoyun","givenName":"Xiaoyun","familyName":"He","affiliation":[],"nameIdentifiers":[]},{"name":"Yao, Lindan","givenName":"Lindan","familyName":"Yao","affiliation":[],"nameIdentifiers":[]},{"name":"Cao, Liping","givenName":"Liping","familyName":"Cao","affiliation":[],"nameIdentifiers":[]},{"name":"Qiu, Junzhi","givenName":"Junzhi","familyName":"Qiu","affiliation":[],"nameIdentifiers":[]},{"name":"Guan, Xiong","givenName":"Xiong","familyName":"Guan","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"A new azaphilone from the entomopathogenic fungus \u003ci\u003eHypocrella\u003c/i\u003e sp."}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Biochemistry"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Pharmacology"},{"subject":"Environmental Sciences not elsewhere classified"},{"subject":"Chemical Sciences not elsewhere classified"},{"subject":"Ecology"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biological Sciences not elsewhere classified"},{"subject":"Cancer"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.c.2047307","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"This report describes the isolation of a new azaphilone, designated hypocrellone A (\u003cb\u003e2\u003c/b\u003e), together with five known compounds (\u003cb\u003e1\u003c/b\u003e, \u003cb\u003e3\u003c/b\u003e–\u003cb\u003e6\u003c/b\u003e) from a submerged culture of the entomopathogenic fungus \u003ci\u003eHypocrella\u003c/i\u003e sp. (isolate WYTY-21). The absolute stereostructures of the two compounds (\u003cb\u003e1\u003c/b\u003e and \u003cb\u003e2\u003c/b\u003e) were elucidated based on 1D and 2D NMR spectroscopic and mass spectrometric data combined with the data from various chemical transformations. Hypocrellone A (\u003cb\u003e2\u003c/b\u003e) and three (\u003cb\u003e3\u003c/b\u003e–\u003cb\u003e6\u003c/b\u003e) of the five known compounds were cytotoxic to hepatoma cells (cell line BEL-7404); IC\u003csub\u003e50\u003c/sub\u003e values ranged from 6.2 to 17.4 μM. At 200 μM, none of the six compounds was toxic to normal human liver cells (cell line HL-7702) or to normal human kidney epithelial cells (cell line HEK-293T).","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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