{"data":{"id":"10.6084/m9.figshare.c.2047301.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2047301.v1","prefix":"10.6084","suffix":"m9.figshare.c.2047301.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Yu, Shan","givenName":"Shan","familyName":"Yu","affiliation":[],"nameIdentifiers":[]},{"name":"Li, Yan","givenName":"Yan","familyName":"Li","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Dong","givenName":"Dong","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Yang, Chong-Ren","givenName":"Chong-Ren","familyName":"Yang","affiliation":[],"nameIdentifiers":[]},{"name":"Xu, Min","givenName":"Min","familyName":"Xu","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Ying-Jun","givenName":"Ying-Jun","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Lv, Jun-Jiang","givenName":"Jun-Jiang","familyName":"Lv","affiliation":[],"nameIdentifiers":[]},{"name":"Zhao, Jian-Qiang","givenName":"Jian-Qiang","familyName":"Zhao","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"New cytotoxic lignan glycosides from \u003ci\u003ePhyllanthus glaucus\u003c/i\u003e"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Inorganic Chemistry"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biological Sciences"},{"subject":"Sociology"},{"subject":"FOS: Sociology","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Ecology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Chemistry"},{"subject":"Earth and Environmental Sciences"},{"subject":"Pharmacology"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.c.2047301","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"During the process of exploring bioactive lead compounds from \u003ci\u003ePhyllanthus\u003c/i\u003e species, two new glycosides including an arylnaphthalene lignan, diphyllin 4-\u003ci\u003eO\u003c/i\u003e-α-l-arabinopyranosyl-(1 → 3)-α-l-arabinopyranoside (\u003cb\u003e1\u003c/b\u003e), and a phenolic compound, 3,4,5-trimethoxybenzyl alcohol 7-\u003ci\u003eO\u003c/i\u003e-α-l-arabinofuranosyl-(1 → 6)-β-d-glucopyranoside (\u003cb\u003e2\u003c/b\u003e), were isolated from the methanol extract of the whole plants of \u003ci\u003ePhyllanthus\u003c/i\u003e\u003ci\u003eglaucus\u003c/i\u003e Wall. ex Müll. Arg. In addition, 31 known compounds, including 19 lignan derivatives (\u003cb\u003e3\u003c/b\u003e–\u003cb\u003e21\u003c/b\u003e), four phenylpropanoids (\u003cb\u003e22\u003c/b\u003e–\u003cb\u003e25\u003c/b\u003e), seven simple phenolics (\u003cb\u003e26\u003c/b\u003e–\u003cb\u003e32\u003c/b\u003e) and one monoterpenoid (\u003cb\u003e33\u003c/b\u003e) were obtained. Their structures were determined on the basis of the HR-ESI-MS, 1D and 2D NMR spectroscopic analysis, and pre-column derivative/chiral HPLC analysis in case of \u003cb\u003e1\u003c/b\u003e for the absolute configurations. All these compounds were obtained from \u003ci\u003eP. glaucus\u003c/i\u003e for the first time. Moreover, the known lignan glycoside, phyllanthusmin C (\u003cb\u003e5\u003c/b\u003e) showed \u003ci\u003ein vitro\u003c/i\u003e cytotoxicities against HL-60, MCF-7 and SW480 cells with IC\u003csub\u003e50\u003c/sub\u003e values of 9.2 ± 0.2, 19.2 ± 1.7 and 20.5 ± 0.9, respectively.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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