{"data":{"id":"10.6084/m9.figshare.c.2044490","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2044490","prefix":"10.6084","suffix":"m9.figshare.c.2044490","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Li, Wei","givenName":"Wei","familyName":"Li","affiliation":[],"nameIdentifiers":[]},{"name":"Zhou, Wei","givenName":"Wei","familyName":"Zhou","affiliation":[],"nameIdentifiers":[]},{"name":"Kim, Sohyun","givenName":"Sohyun","familyName":"Kim","affiliation":[],"nameIdentifiers":[]},{"name":"Koo, Jung-Eun","givenName":"Jung-Eun","familyName":"Koo","affiliation":[],"nameIdentifiers":[]},{"name":"Kim, Yuna","givenName":"Yuna","familyName":"Kim","affiliation":[],"nameIdentifiers":[]},{"name":"Koh, Young-Sang","givenName":"Young-Sang","familyName":"Koh","affiliation":[],"nameIdentifiers":[]},{"name":"Shim, Sang Hee","givenName":"Sang Hee","familyName":"Shim","affiliation":[],"nameIdentifiers":[]},{"name":"Yeul Ma, Jin","givenName":"Jin","familyName":"Yeul Ma","affiliation":[],"nameIdentifiers":[]},{"name":"Kim, Young Ho","givenName":"Young Ho","familyName":"Kim","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Three new secoiridoid glycosides from the rhizomes and roots of \u003ci\u003eGentiana scabra\u003c/i\u003e and their anti-inflammatory activities"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Ecology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Chemistry"},{"subject":"Earth and Environmental Sciences"},{"subject":"Pharmacology"},{"subject":"Microbiology"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Three new (\u003cb\u003e1\u003c/b\u003e–\u003cb\u003e3\u003c/b\u003e) and 17 known (\u003cb\u003e4\u003c/b\u003e–\u003cb\u003e20\u003c/b\u003e) iridoid and secoiridoid glycosides were isolated from a methanol extract of the rhizomes and roots of \u003ci\u003eGentiana scabra\u003c/i\u003e. Their chemical structures were elucidated from 1D and 2D NMR, IR absorption, and HR-ESI-MS spectra, as well as comparisons of these data with reported values. The effects of the isolated compounds on lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells were investigated. Compounds \u003cb\u003e6\u003c/b\u003e, \u003cb\u003e10\u003c/b\u003e and \u003cb\u003e20\u003c/b\u003e exhibited significant inhibitory effects on LPS-induced IL-12 p40 and IL-6 production with IC\u003csub\u003e50\u003c/sub\u003e values of 1.62–14.29 μM. Compound \u003cb\u003e10\u003c/b\u003e also showed a strong inhibitory effect on the LPS-stimulated production of TNF-α with an IC\u003csub\u003e50\u003c/sub\u003e value of 10.45 μM.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"PD94bWwgdmVyc2lvbj0iMS4wIiBlbmNvZGluZz0iVVRGLTgiPz4KPHJlc291cmNlIHhtbG5zPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCIgeG1sbnM6eHNpPSJodHRwOi8vd3d3LnczLm9yZy8yMDAxL1hNTFNjaGVtYS1pbnN0YW5jZSIgeHNpOnNjaGVtYUxvY2F0aW9uPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCBodHRwOi8vc2NoZW1hLmRhdGFjaXRlLm9yZy9tZXRhL2tlcm5lbC00LjQvbWV0YWRhdGEueHNkIj4KICA8aWRlbnRpZmllciBpZGVudGlmaWVyVHlwZT0iRE9JIj4xMC42MDg0L005LkZJR1NIQVJFLkMuMjA0NDQ5MDwvaWRlbnRpZmllcj4KICA8Y3JlYXRvcnM+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPldlaSBMaTwvY3JlYXRvck5hbWU+CiAgICAgIDxnaXZlbk5hbWU+V2VpPC9naXZlbk5hbWU+CiAgICAgIDxmYW1pbHlOYW1lPkxpPC9mYW1pbHlOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5XZWkgWmhvdTwvY3JlYXRvck5hbWU+CiAgICAgIDxnaXZlbk5hbWU+V2VpPC9naXZlbk5hbWU+CiAgICAgIDxmYW1pbHlOYW1lPlpob3U8L2ZhbWlseU5hbWU+CiAgICA8L2NyZWF0b3I+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPlNvaHl1biBLaW08L2NyZWF0b3JOYW1lPgogICAgICA8Z2l2ZW5OYW1lPlNvaHl1bjwvZ2l2ZW5OYW1lPgogICAgICA8ZmFtaWx5TmFtZT5LaW08L2ZhbWlseU5hbWU+CiAgICA8L2NyZWF0b3I+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPkp1bmctRXVuIEtvbzwvY3JlYXRvck5hbWU+CiAgICAgIDxnaXZlbk5hbWU+SnVuZy1FdW48L2dpdmVuTmFtZT4KICAgICAgPGZhbWlseU5hbWU+S29vPC9mYW1pbHlOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5ZdW5hIEtpbTwvY3JlYXRvck5hbWU+CiAgICAgIDxnaXZlbk5hbWU+WXVuYTwvZ2l2ZW5OYW1lPgogICAgICA8ZmFtaWx5TmFtZT5LaW08L2ZhbWlseU5hbWU+CiAgICA8L2NyZWF0b3I+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPllvdW5nLVNhbmcgS29oPC9jcmVhdG9yTmFtZT4KICAgICAgPGdpdmVuTmFtZT5Zb3VuZy1TYW5nPC9naXZlbk5hbWU+CiAgICAgIDxmYW1pbHlOYW1lPktvaDwvZmFtaWx5TmFtZT4KICAgIDwvY3JlYXRvcj4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+U2FuZyBIZWUgU2hpbTwvY3JlYXRvck5hbWU+CiAgICAgIDxnaXZlbk5hbWU+U2FuZyBIZWU8L2dpdmVuTmFtZT4KICAgICAgPGZhbWlseU5hbWU+U2hpbTwvZmFtaWx5TmFtZT4KICAgIDwvY3JlYXRvcj4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+SmluIFlldWwgTWE8L2NyZWF0b3JOYW1lPgogICAgICA8Z2l2ZW5OYW1lPkppbjwvZ2l2ZW5OYW1lPgogICAgICA8ZmFtaWx5TmFtZT5ZZXVsIE1hPC9mYW1pbHlOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5Zb3VuZyBIbyBLaW08L2NyZWF0b3JOYW1lPgogICAgICA8Z2l2ZW5OYW1lPllvdW5nIEhvPC9naXZlbk5hbWU+CiAgICAgIDxmYW1pbHlOYW1lPktpbTwvZmFtaWx5TmFtZT4KICAgIDwvY3JlYXRvcj4KICA8L2NyZWF0b3JzPgogIDx0aXRsZXM+CiAgICA8dGl0bGU+VGhyZWUgbmV3IHNlY29pcmlkb2lkIGdseWNvc2lkZXMgZnJvbSB0aGUgcmhpem9tZXMgYW5kIHJvb3RzIG9mICZsdDtpJmd0O0dlbnRpYW5hIHNjYWJyYSZsdDsvaSZndDsgYW5kIHRoZWlyIGFudGktaW5mbGFtbWF0b3J5IGFjdGl2aXRpZXM8L3RpdGxlPgogIDwvdGl0bGVzPgogIDxkZXNjcmlwdGlvbnM+CiAgICA8ZGVzY3JpcHRpb24gZGVzY3JpcHRpb25UeXBlPSJBYnN0cmFjdCI+Jmx0O2RpdiZndDsmbHQ7cCZndDtUaHJlZSBuZXcgKCZsdDtiJmd0OzEmbHQ7L2ImZ3Q74oCTJmx0O2ImZ3Q7MyZsdDsvYiZndDspIGFuZCAxNyBrbm93biAoJmx0O2ImZ3Q7NCZsdDsvYiZndDvigJMmbHQ7YiZndDsyMCZsdDsvYiZndDspIGlyaWRvaWQgYW5kIHNlY29pcmlkb2lkIGdseWNvc2lkZXMgd2VyZSBpc29sYXRlZCBmcm9tIGEgbWV0aGFub2wgZXh0cmFjdCBvZiB0aGUgcmhpem9tZXMgYW5kIHJvb3RzIG9mICZsdDtpJmd0O0dlbnRpYW5hIHNjYWJyYSZsdDsvaSZndDsuIFRoZWlyIGNoZW1pY2FsIHN0cnVjdHVyZXMgd2VyZSBlbHVjaWRhdGVkIGZyb20gMUQgYW5kIDJEIE5NUiwgSVIgYWJzb3JwdGlvbiwgYW5kIEhSLUVTSS1NUyBzcGVjdHJhLCBhcyB3ZWxsIGFzIGNvbXBhcmlzb25zIG9mIHRoZXNlIGRhdGEgd2l0aCByZXBvcnRlZCB2YWx1ZXMuIFRoZSBlZmZlY3RzIG9mIHRoZSBpc29sYXRlZCBjb21wb3VuZHMgb24gbGlwb3BvbHlzYWNjaGFyaWRlIChMUFMpLXN0aW11bGF0ZWQgYm9uZSBtYXJyb3ctZGVyaXZlZCBkZW5kcml0aWMgY2VsbHMgd2VyZSBpbnZlc3RpZ2F0ZWQuIENvbXBvdW5kcyAmbHQ7YiZndDs2Jmx0Oy9iJmd0OywgJmx0O2ImZ3Q7MTAmbHQ7L2ImZ3Q7IGFuZCAmbHQ7YiZndDsyMCZsdDsvYiZndDsgZXhoaWJpdGVkIHNpZ25pZmljYW50IGluaGliaXRvcnkgZWZmZWN0cyBvbiBMUFMtaW5kdWNlZCBJTC0xMiBwNDAgYW5kIElMLTYgcHJvZHVjdGlvbiB3aXRoIElDJmx0O3N1YiZndDs1MCZsdDsvc3ViJmd0OyB2YWx1ZXMgb2YgMS42MuKAkzE0LjI5wqDOvE0uIENvbXBvdW5kICZsdDtiJmd0OzEwJmx0Oy9iJmd0OyBhbHNvIHNob3dlZCBhIHN0cm9uZyBpbmhpYml0b3J5IGVmZmVjdCBvbiB0aGUgTFBTLXN0aW11bGF0ZWQgcHJvZHVjdGlvbiBvZiBUTkYtzrEgd2l0aCBhbiBJQyZsdDtzdWImZ3Q7NTAmbHQ7L3N1YiZndDsgdmFsdWUgb2YgMTAuNDXCoM68TS4mbHQ7L3AmZ3Q7Jmx0Oy9kaXYmZ3Q7PC9kZXNjcmlwdGlvbj4KICA8L2Rlc2NyaXB0aW9ucz4KICA8c3ViamVjdHM+CiAgICA8c3ViamVjdD5CaW9sb2dpY2FsIFNjaWVuY2VzPC9zdWJqZWN0PgogICAgPHN1YmplY3Q+SW1tdW5vbG9neTwvc3ViamVjdD4KICAgIDxzdWJqZWN0PkVjb2xvZ3k8L3N1YmplY3Q+CiAgICA8c3ViamVjdD5DaGVtaXN0cnk8L3N1YmplY3Q+CiAgICA8c3ViamVjdD5FYXJ0aCBhbmQgRW52aXJvbm1lbnRhbCBTY2llbmNlczwvc3ViamVjdD4KICAgIDxzdWJqZWN0PlBoYXJtYWNvbG9neTwvc3ViamVjdD4KICAgIDxzdWJqZWN0Pk1pY3JvYmlvbG9neTwvc3ViamVjdD4KICAgIDxzdWJqZWN0PkJpb2NoZW1pc3RyeTwvc3ViamVjdD4KICA8L3N1YmplY3RzPgogIDxwdWJsaXNoZXI+VGF5bG9yICZhbXA7IEZyYW5jaXM8L3B1Ymxpc2hlcj4KICA8cHVibGljYXRpb25ZZWFyPjIwMTU8L3B1YmxpY2F0aW9uWWVhcj4KICA8ZGF0ZXM+CiAgICA8ZGF0ZSBkYXRlVHlwZT0iQ3JlYXRlZCI+MjAxNS0xMi0wNTwvZGF0ZT4KICAgIDxkYXRlIGRhdGVUeXBlPSJVcGRhdGVkIj4yMDE5LTA4LTE5PC9kYXRlPgogIDwvZGF0ZXM+CiAgPHJlc291cmNlVHlwZSByZXNvdXJjZVR5cGVHZW5lcmFsPSJDb2xsZWN0aW9uIj5Db2xsZWN0aW9uPC9yZXNvdXJjZVR5cGU+CiAgPHJpZ2h0c0xpc3Q+CiAgICA8cmlnaHRzIHJpZ2h0c1VSST0iaHR0cHM6Ly9jcmVhdGl2ZWNvbW1vbnMub3JnL2xpY2Vuc2VzL2J5LzQuMC8iPkNDIEJZIDQuMDwvcmlnaHRzPgogIDwvcmlnaHRzTGlzdD4KPC9yZXNvdXJjZT4=","url":"https://tandf.figshare.com/collections/Three_new_secoiridoid_glycosides_from_the_rhizomes_and_roots_of_i_Gentiana_scabra_i_and_their_anti_inflammatory_activities/2044490","contentUrl":null,"metadataVersion":2,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2015-12-05T17:28:46.000Z","registered":"2015-12-05T17:28:47.000Z","published":"2015","updated":"2024-03-21T08:40:24.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.c.2044490","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}