{"data":{"id":"10.6084/m9.figshare.c.2033576","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2033576","prefix":"10.6084","suffix":"m9.figshare.c.2033576","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Xu, Yuqing","givenName":"Yuqing","familyName":"Xu","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Jingzheng","givenName":"Jingzheng","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Liu, Jing","givenName":"Jing","familyName":"Liu","affiliation":[],"nameIdentifiers":[]},{"name":"Li, Sai","givenName":"Sai","familyName":"Li","affiliation":[],"nameIdentifiers":[]},{"name":"Li, Cheng","givenName":"Cheng","familyName":"Li","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Wen","givenName":"Wen","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Ma, Rong","givenName":"Rong","familyName":"Ma","affiliation":[],"nameIdentifiers":[]},{"name":"Liu, Yi","givenName":"Yi","familyName":"Liu","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Luteolin attenuate the d-galactose-induced renal damage by attenuation of oxidative stress and inflammation"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Science Policy"},{"subject":"Marine Biology"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Ecology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Chemistry"},{"subject":"Earth and Environmental Sciences"},{"subject":"Physiology"},{"subject":"Molecular Biology"},{"subject":"Genetics"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Luteolin is reported to have antioxidant and anti-inflammatory properties. In this study, we investigated the protective effect of luteolin against the renal damage induced by d-galactose (d-gal). The levels of creatinine (Cr) and urea nitrogen (BUN) were evaluated in plasma, kidney sections were stained with haematoxylin–eosin, followed by assessment of the antioxidant and anti-inflammatory activity. Furthermore, we also investigated the expression of the p38 mitogen-activated protein kinase (p38 MAPK) and its phosphorylated activation. The results of luteolin treatment showed that the renal damages were attenuated. Luteolin could significantly ameliorate d-gal-induced oxidative damage and suppress the inflammatory response. Moreover, the result also shows that luteolin could significantly inhibit the p38 MAPK phosphorylation in the kidneys from the model of d-gal-treated mice. Therefore, our research suggests that luteolin might be involved in the attenuated oxidative stress and inflammatory responses, hence the protective effects against d-gal-induced renal damage.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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