{"data":{"id":"10.6084/m9.figshare.c.2032943","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2032943","prefix":"10.6084","suffix":"m9.figshare.c.2032943","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Wang, Na","givenName":"Na","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"She, Junjun","givenName":"Junjun","familyName":"She","affiliation":[],"nameIdentifiers":[]},{"name":"Liu, Wei","givenName":"Wei","familyName":"Liu","affiliation":[],"nameIdentifiers":[]},{"name":"Shi, Jing","givenName":"Jing","familyName":"Shi","affiliation":[],"nameIdentifiers":[]},{"name":"Yang, Qi","givenName":"Qi","familyName":"Yang","affiliation":[],"nameIdentifiers":[]},{"name":"Shi, Bingyin","givenName":"Bingyin","familyName":"Shi","affiliation":[],"nameIdentifiers":[]},{"name":"Hou, Peng","givenName":"Peng","familyName":"Hou","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Frequent amplification of \u003ci\u003ePTP1B\u003c/i\u003e is associated with poor survival of gastric cancer patients"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Infectious Diseases"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Science Policy"},{"subject":"Cancer"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Chemistry"},{"subject":"Molecular Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Medicine"},{"subject":"Physics"},{"subject":"Biochemistry"},{"subject":"Biophysics"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"The protein tyrosine phosphatase 1B (\u003ci\u003ePTP1B\u003c/i\u003e), a non-transmembrane protein tyrosine phosphatase, has been implicated in gastric pathogenesis. Several lines of recent evidences have shown that \u003ci\u003ePTP1B\u003c/i\u003e is highly amplified in breast and prostate cancers. The aim of this study was to investigate \u003ci\u003ePTP1B\u003c/i\u003e amplification in gastric cancer and its association with poor prognosis of gastric cancer patients, and further determine the role of \u003ci\u003ePTP1B\u003c/i\u003e in gastric tumorigenesis. Our data demonstrated that \u003ci\u003ePTP1B\u003c/i\u003e was significantly up-regulated in gastric cancer tissues as compared with matched normal gastric tissues by using quantitative RT-PCR (qRT-PCR) assay. In addition, copy number analysis showed that \u003ci\u003ePTP1B\u003c/i\u003e was amplified in 68/131 (51.9%) gastric cancer cases, whereas no amplification was found in the control subjects. Notably, \u003ci\u003ePTP1B\u003c/i\u003e amplification was positively associated with its protein expression, and was significantly related to poor survival of gastric cancer patients. Knocking down \u003ci\u003ePTP1B\u003c/i\u003e expression in gastric cancer cells significantly inhibited cell proliferation, colony formation, migration and invasion, and induced cell cycle arrested and apoptosis. Mechanically, \u003ci\u003ePTP1B\u003c/i\u003e promotes gastric cancer cell proliferation, survival and invasiveness through modulating Src-related signaling pathways, such as Src/Ras/MAPK and Src/phosphatidylinositol-3-kinase (PI3K)/Akt pathways. Collectively, our data demonstrated frequent overexpression and amplification \u003ci\u003ePTP1B\u003c/i\u003e in gastric cancer, and further determined the oncogenic role of \u003ci\u003ePTP1B\u003c/i\u003e in gastric carcinogenesis. Importantly, \u003ci\u003ePTP1B\u003c/i\u003e amplification predicts poor survival of gastric cancer patients.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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