{"data":{"id":"10.6084/m9.figshare.c.2031197.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2031197.v1","prefix":"10.6084","suffix":"m9.figshare.c.2031197.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Liao, Yuanhong","givenName":"Yuanhong","familyName":"Liao","affiliation":[],"nameIdentifiers":[]},{"name":"Ling, Jianya","givenName":"Jianya","familyName":"Ling","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Guoying","givenName":"Guoying","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Liu, Fengjun","givenName":"Fengjun","familyName":"Liu","affiliation":[],"nameIdentifiers":[]},{"name":"Tao, Shengce","givenName":"Shengce","familyName":"Tao","affiliation":[],"nameIdentifiers":[]},{"name":"Han, Zeguang","givenName":"Zeguang","familyName":"Han","affiliation":[],"nameIdentifiers":[]},{"name":"Chen, Saijuan","givenName":"Saijuan","familyName":"Chen","affiliation":[],"nameIdentifiers":[]},{"name":"Chen, Zhu","givenName":"Zhu","familyName":"Chen","affiliation":[],"nameIdentifiers":[]},{"name":"Le, Huangying","givenName":"Huangying","familyName":"Le","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Cordycepin induces cell cycle arrest and apoptosis by inducing DNA damage and up-regulation of p53 in Leukemia cells"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Virology"},{"subject":"Infectious Diseases"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Hematology"},{"subject":"Cancer"},{"subject":"Developmental Biology"},{"subject":"Biological Sciences"},{"subject":"Chemistry"},{"subject":"Physiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"Cell Biology"},{"subject":"Microbiology"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.c.2031197","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Cordycepin, an adenosine analog derived from \u003ci\u003eCordyceps militaris\u003c/i\u003e has been shown to exert anti-tumor activity in many ways. However, the mechanisms by which cordycepin contributes to the anti-tumor still obscure. Here our present work showed that cordycepin inhibits cell growth in NB-4 and U937 cells by inducing apoptosis. Further study showed that cordycepin increases the expression of p53 which promotes the release of cytochrome \u003ci\u003ec\u003c/i\u003e from mitochondria to the cytosol. The released cytochrome \u003ci\u003ec\u003c/i\u003e can then activate caspase-9 and trigger intrinsic apoptosis. Cordycepin also blocks MAPK pathway by inhibiting the phosphorylation of ERK1/2, and thus sensitizes the apoptosis. In addition, our results showed that cordycepin inhibits the expression of cyclin A2, cyclin E, and CDK2, which leads to the accumulation of cells in S-phase. Moreover, our study showed that cordycepin induces DNA damage and causes degradation of Cdc25A, suggesting that cordycepin-induced S-phase arrest involves activation of Chk2-Cdc25A pathway. In conclusion, cordycepin-induced DNA damage initiates cell cycle arrest and apoptosis which leads to the growth inhibition of NB-4 and U937 cells.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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