{"data":{"id":"10.6084/m9.figshare.c.2031176.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2031176.v1","prefix":"10.6084","suffix":"m9.figshare.c.2031176.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Wei, Ying","givenName":"Ying","familyName":"Wei","affiliation":[],"nameIdentifiers":[]},{"name":"Song, Xiaoyu","givenName":"Xiaoyu","familyName":"Song","affiliation":[],"nameIdentifiers":[]},{"name":"Liu, Mengling","givenName":"Mengling","familyName":"Liu","affiliation":[],"nameIdentifiers":[]},{"name":"Ionita-Laza, Iuliana","givenName":"Iuliana","familyName":"Ionita-Laza","affiliation":[],"nameIdentifiers":[]},{"name":"Reibman, Joan","givenName":"Joan","familyName":"Reibman","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Quantile Regression in the Secondary Analysis of Case-Control Data"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Science Policy"},{"subject":"Mathematics"},{"subject":"FOS: Mathematics","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biological Sciences"},{"subject":"Sociology"},{"subject":"FOS: Sociology","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Chemistry"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Medicine"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsPreviousVersionOf","relatedIdentifier":"10.6084/m9.figshare.c.2031176","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Case-control design is widely used in epidemiology and other fields to identify factors associated with a disease. Data collected from existing case-control studies can also provide a cost-effective way to investigate the association of risk factors with secondary outcomes. When the secondary outcome is a continuous random variable, most of the existing methods focus on the statistical inference on the mean of the secondary outcome. In this paper, we propose a quantile-based approach to facilitating a comprehensive investigation of covariates’ effects on multiple quantiles of the secondary outcome. We construct a new family of estimating equations combining observed and pseudo outcomes, which lead to consistent estimation of conditional quantiles using case-control data. Simulations are conducted to evaluate the performance of our proposed approach, and a case-control study on genetic association with asthma is used to demonstrate the method.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/collections/Quantile_Regression_in_the_Secondary_Analysis_of_Case_Control_Data/2031176/1","contentUrl":null,"metadataVersion":3,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2015-12-05T19:30:18.000Z","registered":"2015-12-05T19:30:19.000Z","published":"2015","updated":"2024-03-21T08:35:40.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.c.2031176.v1","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}