{"data":{"id":"10.6084/m9.figshare.c.2030063.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2030063.v1","prefix":"10.6084","suffix":"m9.figshare.c.2030063.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Lu, Han","givenName":"Han","familyName":"Lu","affiliation":[],"nameIdentifiers":[]},{"name":"Liu, Bin","givenName":"Bin","familyName":"Liu","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Fu-Jun","givenName":"Fu-Jun","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Jin","givenName":"Jin","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Dong, Rong","givenName":"Rong","familyName":"Dong","affiliation":[],"nameIdentifiers":[]},{"name":"Chen, Lei","givenName":"Lei","familyName":"Chen","affiliation":[],"nameIdentifiers":[]},{"name":"Qu, Dong-Mei","givenName":"Dong-Mei","familyName":"Qu","affiliation":[],"nameIdentifiers":[]},{"name":"Lu, Yan","givenName":"Yan","familyName":"Lu","affiliation":[],"nameIdentifiers":[]},{"name":"Yu, Bu-Wei","givenName":"Bu-Wei","familyName":"Yu","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"The E3 ligase APC/C-Cdh1 regulates MEF2A-dependent transcription by targeting SUMO-specific protease 2 for ubiquitination and degradation"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Computational Biology"},{"subject":"Plant Biology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Infectious Diseases"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Mental Health"},{"subject":"Cancer"},{"subject":"Developmental Biology"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Meta Science"},{"subject":"Chemistry"},{"subject":"Earth and Environmental Sciences"},{"subject":"Molecular Biology"},{"subject":"Genetics"},{"subject":"Cell Biology"},{"subject":"Microbiology"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.c.2030063","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Activity-dependent stimuli induced a calcineurin-mediated dephosphorylation of the transcriptional factor MEF2A at serine408 and promoted a switch from SUMOylation to acetylation at lysine403 which led to MEF2A transcriptional activation. We previously identified SENP2 is the de-SUMOylation enzyme for MEF2A and promotes MEF2A-dependent transcription. We report here a requirement for APC\u003csup\u003eCdh1\u003c/sup\u003e-SENP2-MEF2A axis in the regulation of MEF2A transcriptional activation. APC\u003csup\u003eCdh1\u003c/sup\u003e interacts with and targets SENP2 for ubiquitination and destruction in the cytoplasm by recognizing a conserved canonical D-box motif in SENP2. Moreover, Cdh1 regulates the transcriptional activity of MEF2A in a SENP2 dependent manner. Activity-dependent stimuli prevented APC\u003csup\u003eCdh1\u003c/sup\u003e-induced SENP2 ubiquitination, promoted SENP2 nuclear accumulations, and caused MEF2A de-SUMOylation and MEF2A acetylation, leading to MEF2A transcriptional activation. Thus, our findings defined a post-transcriptional mechanism underlying activity-dependent stimuli-induced MEF2A transcriptional activation.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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