{"data":{"id":"10.6084/m9.figshare.c.2005286.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2005286.v1","prefix":"10.6084","suffix":"m9.figshare.c.2005286.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Yang, Yi","givenName":"Yi","familyName":"Yang","affiliation":[],"nameIdentifiers":[]},{"name":"Akber Aisa, Haji","givenName":"Haji","familyName":"Akber Aisa","affiliation":[],"nameIdentifiers":[]},{"name":"Gu, Dongyu","givenName":"Dongyu","familyName":"Gu","affiliation":[],"nameIdentifiers":[]},{"name":"Hang, Ba","givenName":"Ba","familyName":"Hang","affiliation":[],"nameIdentifiers":[]},{"name":"Lv, Qiaoying","givenName":"Qiaoying","familyName":"Lv","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Characterization and Identification of the Chemical Compositions in a Traditional Uighur Medicine Prescription Yizhihao Granule by LC–ESI-QTOF-MS"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Chemistry"},{"subject":"Earth and Environmental Sciences"},{"subject":"Biotechnology"},{"subject":"Pharmacology"},{"subject":"Microbiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Engineering"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.c.2005286","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"An efficient method was developed and established for the rapid analysis of a traditional Uighur medicinal prescription, Yizhihao granule, by liquid chromatography-Quadrupole time-of-flight tandem mass spectrometry. HPLC was performed with a Poroshell 120-EC18 column with 2.7 µm particle size using A gradient elution system. A quadrupole time-of-flight analyzer was used for the determination of accurate mass of the protonated or deprotonated molecules and fragment ions. Sixty-six constituents including amino acids, organic acids (aliphatic acids, benzoic acid derivatives, and chlorogenic acids), alkaloids (indole and quinazolinone type), flavonoids (C,O-glycoside, C-glycosides, O-glycosides, and aglycone), sesquiterpenoids (rupestonic acid derivatives), and other compounds were identified or tentatively characterized in Yizhihao granule as a presented application of prescription according to the accurate mass, MS/MS data, and relevant literature. Additionally, the fragmentation pathways of two rupestonic acid derivatives were proposed. The relationship between structure features and fragmentation patterns were investigated thoroughly and applied in the on-line analysis to deduce the composition of traditional Uighur herbal prescription. The present method and results should be beneficial in the development of traditional Uighur herbal prescription.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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