{"data":{"id":"10.6084/m9.figshare.c.1999244.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.1999244.v1","prefix":"10.6084","suffix":"m9.figshare.c.1999244.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Chen, Rong-Rong","givenName":"Rong-Rong","familyName":"Chen","affiliation":[],"nameIdentifiers":[]},{"name":"Liu, Zhao-Kun","givenName":"Zhao-Kun","familyName":"Liu","affiliation":[],"nameIdentifiers":[]},{"name":"Liu, Fang","givenName":"Fang","familyName":"Liu","affiliation":[],"nameIdentifiers":[]},{"name":"Ng, Tzi Bun","givenName":"Tzi Bun","familyName":"Ng","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Antihyperglycaemic mechanisms of an aceteoside polymer from rose flowers and a polysaccharide–protein complex from abalone mushroom"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Infectious Diseases"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Inorganic Chemistry"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Developmental Biology"},{"subject":"Biological Sciences"},{"subject":"Chemistry"},{"subject":"Biotechnology"},{"subject":"Molecular Biology"},{"subject":"Cell Biology"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.c.1999244","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Oral administration of an aceteoside polymer from rose \u003ci\u003eRosa rugosa\u003c/i\u003e (P\u003csub\u003e1-b\u003c/sub\u003e) and a polysaccharide–peptide complex from abalone mushroom \u003ci\u003ePleurotus abalonus\u003c/i\u003e (LB-1b), both with antioxidant activity, produced antihyperglycaemic effects in alloxan-induced diabetic mice. The expression of insulin, superoxide dismutase and pancreas duodenum homeobox factor-1 essential for pancreatic islet function as estimated by real-time PCR was augmented. The reactive oxygen species-scavenging ability of the rose constituent was notably stronger than the mushroom constituent. Thus, the two biomolecules protected the pancreas from oxidative stress, elevated pancreatic insulin expression and lowered circulating glucose 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