{"data":{"id":"10.6084/m9.figshare.97654.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.97654.v1","prefix":"10.6084","suffix":"m9.figshare.97654.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Diaz-Cano, Salvador J.","nameType":"Personal","givenName":"Salvador J.","familyName":"Diaz-Cano","affiliation":[],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-1245-2859","nameIdentifierScheme":"ORCID"}]},{"name":"H J Wolfe","affiliation":[],"nameIdentifiers":[]},{"name":"M Harjacek","affiliation":[],"nameIdentifiers":[]},{"name":"A C Steere","affiliation":[],"nameIdentifiers":[]},{"name":"J Coburn","affiliation":[],"nameIdentifiers":[]},{"name":"R Ruthazer","affiliation":[],"nameIdentifiers":[]},{"name":"B A Alman","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Prominent expression of mRNA for proinflammatory cytokines in synovium in patients with juvenile rheumatoid arthritis or chronic Lyme arthritis"}],"publisher":"figshare","container":{},"publicationYear":2012,"subjects":[{"subject":"Medicine"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2012-11-16","dateType":"Created"},{"date":"2016-01-11","dateType":"Updated"},{"date":"2012","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsPreviousVersionOf","relatedIdentifier":"10.6084/m9.figshare.97654","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["0 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"OBJECTIVE: To examine the cytokine profiles in synovium of patients with juvenile rheumatoid arthritis (JRA) or Lyme arthritis, 2 chronic inflammatory arthritides that affect children.\u003cbr\u003e\u003cbr\u003e METHODS: We used in situ hybridization with specific riboprobes to determine the expression of mRNA for proinflammatory or antiinflammatory cytokines in synovial samples from 5 patients with early, untreated JRA, 15 patients with late, treated JRA, and 9 patients with chronic Lyme arthritis. For comparison, synovia were examined from 6 patients with rheumatoid or psoriatic arthritis, and from 9 patients with various orthopedic conditions.\u003cbr\u003e\u003cbr\u003e RESULTS: Among the children with early, untreated JRA, a median of 3 to 8% of inflammatory cells in synovial samples expressed mRNA for the proinflammatory cytokines interleukin 1beta (IL-1beta), tumor necrosis factor-alpha(TNF-alpha), or interferon-gamma (IFN-gamma). Although a median of 3.9% of the cells expressed mRNA for the antiinflammatory cytokine IL-10, none had IL-4 mRNA. Most of the patients with late, treated JRA, chronic Lyme arthritis, rheumatoid, or psoriatic arthritis had mRNA for each of these proinflammatory cytokines in about 1% of the cells, whereas mRNA for the antiinflammatory cytokines was less frequent. The inflammatory cell density was much less in the synovium of patients with various orthopedic conditions, but about 1% of the infiltrating cells expressed mRNA for at least one of the proinflammatory cytokines.\u003cbr\u003e\u003cbr\u003e CONCLUSION: Patients with early or late JRA or chronic Lyme arthritis have expression of mRNA in synovial tissue primarily for proinflammatory cytokines, with less expression of antiinflammatory cytokines.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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  <identifier identifierType="DOI">10.6084/M9.FIGSHARE.97654.V1</identifier>
  <creators>
    <creator>
      <creatorName>Salvador J. Diaz-Cano</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org">0000-0003-1245-2859</nameIdentifier>
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    <creator>
      <creatorName>H J Wolfe</creatorName>
    </creator>
    <creator>
      <creatorName>M Harjacek</creatorName>
    </creator>
    <creator>
      <creatorName>A C Steere</creatorName>
    </creator>
    <creator>
      <creatorName>J Coburn</creatorName>
    </creator>
    <creator>
      <creatorName>R Ruthazer</creatorName>
    </creator>
    <creator>
      <creatorName>B A Alman</creatorName>
    </creator>
  </creators>
  <titles>
    <title>Prominent expression of mRNA for proinflammatory cytokines in synovium in patients with juvenile rheumatoid arthritis or chronic Lyme arthritis</title>
  </titles>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;OBJECTIVE: To examine the cytokine profiles in synovium of patients with &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url=http://europepmc.org/search/?page=1&amp;query=%22juvenile%20rheumatoid%20arthritis%22" target="_blank"&gt;juvenile rheumatoid arthritis&lt;/a&gt; (&lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url=http://europepmc.org/search/?page=1&amp;query=%22JRA%22" target="_blank"&gt;JRA&lt;/a&gt;) or &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url=http://europepmc.org/search/?page=1&amp;query=%22Lyme%20arthritis%22" target="_blank"&gt;Lyme arthritis&lt;/a&gt;, 2 chronic &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url=http://europepmc.org/search/?page=1&amp;query=%22inflammatory%20arthritides%22" target="_blank"&gt;inflammatory arthritides&lt;/a&gt; that affect children.&lt;br&gt;&lt;br&gt; METHODS: We used in situ hybridization with specific riboprobes to determine the expression of &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url_Chemicals=http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A33699" target="_blank"&gt;mRNA&lt;/a&gt; for proinflammatory or antiinflammatory cytokines in synovial samples from 5 patients with early, untreated &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url=http://europepmc.org/search/?page=1&amp;query=%22JRA%22" target="_blank"&gt;JRA&lt;/a&gt;, 15 patients with late, treated &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url=http://europepmc.org/search/?page=1&amp;query=%22JRA%22" target="_blank"&gt;JRA&lt;/a&gt;, and 9 patients with chronic &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url=http://europepmc.org/search/?page=1&amp;query=%22Lyme%20arthritis%22" target="_blank"&gt;Lyme arthritis&lt;/a&gt;. For comparison, synovia were examined from 6 patients with rheumatoid or &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url=http://europepmc.org/search/?page=1&amp;query=%22psoriatic%20arthritis%22" target="_blank"&gt;psoriatic arthritis&lt;/a&gt;, and from 9 patients with various orthopedic conditions.&lt;br&gt;&lt;br&gt; RESULTS: Among the children with early, untreated &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url=http://europepmc.org/search/?page=1&amp;query=%22JRA%22" target="_blank"&gt;JRA&lt;/a&gt;, a median of 3 to 8% of inflammatory cells in synovial samples expressed &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url_Chemicals=http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A33699" target="_blank"&gt;mRNA&lt;/a&gt; for the proinflammatory cytokines interleukin 1beta (&lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url_gene_protein=http://www.uniprot.org/uniprot/?query=IL-1beta&amp;sort=score" target="_blank"&gt;IL-1beta&lt;/a&gt;), &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url_gene_protein=http://www.uniprot.org/uniprot/?query=tumor%20necrosis%20factor&amp;sort=score" target="_blank"&gt;tumor necrosis factor&lt;/a&gt;-alpha(&lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url_gene_protein=http://www.uniprot.org/uniprot/?query=TNF-alpha&amp;sort=score" target="_blank"&gt;TNF-alpha&lt;/a&gt;), or &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url_gene_protein=http://www.uniprot.org/uniprot/?query=interferon-gamma&amp;sort=score" target="_blank"&gt;interferon-gamma&lt;/a&gt; (&lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url_gene_protein=http://www.uniprot.org/uniprot/?query=IFN-gamma&amp;sort=score" target="_blank"&gt;IFN-gamma&lt;/a&gt;). Although a median of 3.9% of the cells expressed &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url_Chemicals=http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A33699" target="_blank"&gt;mRNA&lt;/a&gt; for the antiinflammatory cytokine &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url_gene_protein=http://www.uniprot.org/uniprot/?query=IL-10&amp;sort=score" target="_blank"&gt;IL-10&lt;/a&gt;, none had &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url_gene_protein=http://www.uniprot.org/uniprot/?query=IL-4&amp;sort=score" target="_blank"&gt;IL-4&lt;/a&gt; &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url_Chemicals=http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A33699" target="_blank"&gt;mRNA&lt;/a&gt;. Most of the patients with late, treated &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url=http://europepmc.org/search/?page=1&amp;query=%22JRA%22" target="_blank"&gt;JRA&lt;/a&gt;, chronic &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url=http://europepmc.org/search/?page=1&amp;query=%22Lyme%20arthritis%22" target="_blank"&gt;Lyme arthritis&lt;/a&gt;, rheumatoid, or &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url=http://europepmc.org/search/?page=1&amp;query=%22psoriatic%20arthritis%22" target="_blank"&gt;psoriatic arthritis&lt;/a&gt; had &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url_Chemicals=http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A33699" target="_blank"&gt;mRNA&lt;/a&gt; for each of these proinflammatory cytokines in about 1% of the cells, whereas &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url_Chemicals=http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A33699" target="_blank"&gt;mRNA&lt;/a&gt; for the antiinflammatory cytokines was less frequent. The inflammatory cell density was much less in the synovium of patients with various orthopedic conditions, but about 1% of the infiltrating cells expressed &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url_Chemicals=http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A33699" target="_blank"&gt;mRNA&lt;/a&gt; for at least one of the proinflammatory cytokines.&lt;br&gt;&lt;br&gt; CONCLUSION: Patients with early or late &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url=http://europepmc.org/search/?page=1&amp;query=%22JRA%22" target="_blank"&gt;JRA&lt;/a&gt; or chronic &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url=http://europepmc.org/search/?page=1&amp;query=%22Lyme%20arthritis%22" target="_blank"&gt;Lyme arthritis&lt;/a&gt; have expression of &lt;a href="http://europepmc.org/abstract/MED/10685820/?whatizit_url_Chemicals=http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A33699" target="_blank"&gt;mRNA&lt;/a&gt; in synovial tissue primarily for proinflammatory cytokines, with less expression of antiinflammatory cytokines.&lt;/p&gt;</description>
  </descriptions>
  <subjects>
    <subject>Medicine</subject>
    <subject>Immunology</subject>
  </subjects>
  <publisher>figshare</publisher>
  <publicationYear>2012</publicationYear>
  <dates>
    <date dateType="Created">2012-11-16</date>
    <date dateType="Updated">2016-01-11</date>
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    <rights rightsURI="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0</rights>
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