{"data":{"id":"10.6084/m9.figshare.776922","type":"dois","attributes":{"doi":"10.6084/m9.figshare.776922","prefix":"10.6084","suffix":"m9.figshare.776922","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Lab, Claus Wilke","nameType":"Personal","givenName":"Claus Wilke","familyName":"Lab","affiliation":[],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-7470-9261","nameIdentifierScheme":"ORCID"}]},{"name":"Spielman, Stephanie J.","nameType":"Personal","givenName":"Stephanie J.","familyName":"Spielman","affiliation":[],"nameIdentifiers":[]},{"name":"Wilke, Claus","nameType":"Personal","givenName":"Claus","familyName":"Wilke","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Membrane Environment Imposes Unique Selection Pressures on Transmembrane Domains of G Protein-Coupled Receptors"}],"publisher":"figshare","container":{},"publicationYear":2013,"subjects":[{"subject":"Molecular Biology"},{"subject":"Computational Biology"},{"subject":"60102 Bioinformatics","subjectScheme":"FOR"},{"subject":"FOS: Computer and information sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Computer and information sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Evolutionary Biology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2013-08-20","dateType":"Created"},{"date":"2015-12-02","dateType":"Updated"},{"date":"2013","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":["698107 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"G protein-coupled receptors (GPCRs) represent one of the largest families of membrane proteins in eukaryotes. In Metazoa, GPCRs play significant roles in a wide variety of cri6cal physiological func6ons, including percep6on and metabolism, and over 40% of pharmaceu6cals target GPCRs [1]. Despite their clear func6onal importance, few studies have examined their evolu6on, or indeed the evolu6on of membrane proteins, which account for up to 35% of an organism’s proteome. Here, we present a large-scale computa6onal study of the molecular evolu6on of over 350 mammalian GPCRs, including up to 27 species per gene [2]. We calculated an evolu6onary rate, dN/dS, or ω, using the HyPhy batch language [4] as well as rela6ve solvent accessibility (RSA) for receptors with available structures at each residue.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://figshare.com/articles/dataset/Membrane_Environment_Imposes_Unique_Selec7on_Pressures_on_Transmembrane_Domains_of_G_Protein_Coupled_Receptors/776922","contentUrl":null,"metadataVersion":2,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2013-08-20T20:19:22.000Z","registered":"2013-08-20T20:19:23.000Z","published":"2013","updated":"2020-09-05T01:33:41.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.776922","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}