{"data":{"id":"10.6084/m9.figshare.768435","type":"dois","attributes":{"doi":"10.6084/m9.figshare.768435","prefix":"10.6084","suffix":"m9.figshare.768435","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Brown, Michael","nameType":"Personal","givenName":"Michael","familyName":"Brown","affiliation":[],"nameIdentifiers":[]},{"name":"Prince, Jessica","nameType":"Personal","givenName":"Jessica","familyName":"Prince","affiliation":[],"nameIdentifiers":[]},{"name":"Lundgren, Alyssa","nameType":"Personal","givenName":"Alyssa","familyName":"Lundgren","affiliation":[],"nameIdentifiers":[]},{"name":"Stadnisky, Michael","nameType":"Personal","givenName":"Michael","familyName":"Stadnisky","affiliation":[],"nameIdentifiers":[]},{"name":"Nash, William","nameType":"Personal","givenName":"William","familyName":"Nash","affiliation":[],"nameIdentifiers":[]},{"name":"Beeber, Amira","nameType":"Personal","givenName":"Amira","familyName":"Beeber","affiliation":[],"nameIdentifiers":[]},{"name":"Turner, Stephen","nameType":"Personal","givenName":"Stephen","familyName":"Turner","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Multiparametric comparative analysis of all pre- and postinfection related immune cell and clinical traits"}],"publisher":"figshare","container":{},"publicationYear":2013,"subjects":[{"subject":"60506 Virology","subjectScheme":"FOR"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Genetics"},{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2013-08-09","dateType":"Created"},{"date":"2016-08-30","dateType":"Updated"},{"date":"2013","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":["440129 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Multiparametric analysis of 233 MA/My x C57L intercross and backcross mice segregating MHC class I Dk. Before murine (M)CMV infection, all mice were weighed and bled. Blood leukocytes were stained with fluorochrome-conjugated mAbs for CD3, CD19, and NK receptors and then analyzed by flow cytometry. NK cell subset light-scattering features, absolute number, frequency, and receptor display intensity were recorded as individual pre-infection traits. Afterward, the mice were infected with MCMV. Spleen and liver tissues were collected 3.5 d later for analysis of postinfection traits, including genomic genotypes and viral load. Spleen leukocytes from infected mice were analyzed as for pre-infection traits. The change in trait values were calculated from the pre- (blood) and post- (spleen) infection trait values. In total, 110 distinct traits were assessed. Multiparametric Pearson correlations were performed in the R (versions 2.15.0 and 2.15.2) computing environment using an automated correlation analysis followed with a strict Bonferroni correction for multiple tests. P-values were corrected for multiple comparisons using both the Benjamini-Hochberg false discovery rate and the Bonferroni Correction.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"PD94bWwgdmVyc2lvbj0iMS4wIiBlbmNvZGluZz0iVVRGLTgiPz4KPHJlc291cmNlIHhtbG5zPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCIgeG1sbnM6eHNpPSJodHRwOi8vd3d3LnczLm9yZy8yMDAxL1hNTFNjaGVtYS1pbnN0YW5jZSIgeHNpOnNjaGVtYUxvY2F0aW9uPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCBodHRwOi8vc2NoZW1hLmRhdGFjaXRlLm9yZy9tZXRhL2tlcm5lbC00LjEvbWV0YWRhdGEueHNkIj4KICA8aWRlbnRpZmllciBpZGVudGlmaWVyVHlwZT0iRE9JIj4xMC42MDg0L005LkZJR1NIQVJFLjc2ODQzNTwvaWRlbnRpZmllcj4KICA8Y3JlYXRvcnM+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPk1pY2hhZWwgQnJvd248L2NyZWF0b3JOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5KZXNzaWNhIFByaW5jZTwvY3JlYXRvck5hbWU+CiAgICA8L2NyZWF0b3I+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPkFseXNzYSBMdW5kZ3JlbjwvY3JlYXRvck5hbWU+CiAgICA8L2NyZWF0b3I+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPk1pY2hhZWwgU3RhZG5pc2t5PC9jcmVhdG9yTmFtZT4KICAgIDwvY3JlYXRvcj4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+V2lsbGlhbSBOYXNoPC9jcmVhdG9yTmFtZT4KICAgIDwvY3JlYXRvcj4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+QW1pcmEgQmVlYmVyPC9jcmVhdG9yTmFtZT4KICAgIDwvY3JlYXRvcj4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+U3RlcGhlbiBUdXJuZXI8L2NyZWF0b3JOYW1lPgogICAgPC9jcmVhdG9yPgogIDwvY3JlYXRvcnM+CiAgPHRpdGxlcz4KICAgIDx0aXRsZT5NdWx0aXBhcmFtZXRyaWMgY29tcGFyYXRpdmUgYW5hbHlzaXMgb2YgYWxsIHByZS0gYW5kIHBvc3RpbmZlY3Rpb24gcmVsYXRlZCBpbW11bmUgY2VsbCBhbmQgY2xpbmljYWwgdHJhaXRzPC90aXRsZT4KICA8L3RpdGxlcz4KICA8ZGVzY3JpcHRpb25zPgogICAgPGRlc2NyaXB0aW9uIGRlc2NyaXB0aW9uVHlwZT0iQWJzdHJhY3QiPiZsdDtwJmd0O011bHRpcGFyYW1ldHJpYyBhbmFseXNpcyBvZiAyMzMgTUEvTXkgeCBDNTdMIGludGVyY3Jvc3MgYW5kIGJhY2tjcm9zcyBtaWNlIHNlZ3JlZ2F0aW5nIE1IQyBjbGFzcyBJIERrLiBCZWZvcmUgbXVyaW5lIChNKUNNViBpbmZlY3Rpb24sIGFsbCBtaWNlIHdlcmUgd2VpZ2hlZCBhbmQgYmxlZC4gQmxvb2QgbGV1a29jeXRlcyB3ZXJlIHN0YWluZWQgd2l0aCBmbHVvcm9jaHJvbWUtY29uanVnYXRlZCBtQWJzIGZvciBDRDMsIENEMTksIGFuZCBOSyByZWNlcHRvcnMgYW5kIHRoZW4gYW5hbHl6ZWQgYnkgZmxvdyBjeXRvbWV0cnkuIE5LIGNlbGwgc3Vic2V0IGxpZ2h0LXNjYXR0ZXJpbmcgZmVhdHVyZXMsIGFic29sdXRlIG51bWJlciwgZnJlcXVlbmN5LCBhbmQgcmVjZXB0b3IgZGlzcGxheSBpbnRlbnNpdHkgd2VyZSByZWNvcmRlZCBhcyBpbmRpdmlkdWFsIHByZS1pbmZlY3Rpb24gdHJhaXRzLiBBZnRlcndhcmQsIHRoZSBtaWNlIHdlcmUgaW5mZWN0ZWQgd2l0aCBNQ01WLiBTcGxlZW4gYW5kIGxpdmVyIHRpc3N1ZXMgd2VyZSBjb2xsZWN0ZWQgMy41IGQgbGF0ZXIgZm9yIGFuYWx5c2lzIG9mIHBvc3RpbmZlY3Rpb24gdHJhaXRzLCBpbmNsdWRpbmcgZ2Vub21pYyBnZW5vdHlwZXMgYW5kIHZpcmFsIGxvYWQuIFNwbGVlbiBsZXVrb2N5dGVzIGZyb20gaW5mZWN0ZWQgbWljZSB3ZXJlIGFuYWx5emVkIGFzIGZvciBwcmUtaW5mZWN0aW9uIHRyYWl0cy4gVGhlIGNoYW5nZSBpbiB0cmFpdCB2YWx1ZXMgd2VyZSBjYWxjdWxhdGVkIGZyb20gdGhlIHByZS0gKGJsb29kKSBhbmQgcG9zdC0gKHNwbGVlbikgaW5mZWN0aW9uIHRyYWl0IHZhbHVlcy4gSW4gdG90YWwsIDExMCBkaXN0aW5jdCB0cmFpdHMgd2VyZSBhc3Nlc3NlZC4gTXVsdGlwYXJhbWV0cmljIFBlYXJzb24gY29ycmVsYXRpb25zIHdlcmUgcGVyZm9ybWVkIGluIHRoZSBSICh2ZXJzaW9ucyAyLjE1LjAgYW5kIDIuMTUuMikgY29tcHV0aW5nIGVudmlyb25tZW50IHVzaW5nIGFuIGF1dG9tYXRlZCBjb3JyZWxhdGlvbiBhbmFseXNpcyBmb2xsb3dlZCB3aXRoIGEgc3RyaWN0IEJvbmZlcnJvbmkgY29ycmVjdGlvbiBmb3IgbXVsdGlwbGUgdGVzdHMuIFAtdmFsdWVzIHdlcmUgY29ycmVjdGVkIGZvciBtdWx0aXBsZSBjb21wYXJpc29ucyB1c2luZyBib3RoIHRoZSBCZW5qYW1pbmktSG9jaGJlcmcgZmFsc2UgZGlzY292ZXJ5IHJhdGUgYW5kIHRoZSBCb25mZXJyb25pIENvcnJlY3Rpb24uJmx0Oy9wJmd0OzwvZGVzY3JpcHRpb24+CiAgPC9kZXNjcmlwdGlvbnM+CiAgPHN1YmplY3RzPgogICAgPHN1YmplY3Qgc2NoZW1lVVJJPSJodHRwOi8vd3d3LmFicy5nb3YuYXUvYXVzc3RhdHMvYWJzQC5uc2YvMC82QkI0MjdBQjk2OTZDMjI1Q0EyNTc0MTgwMDA0NDYzRSIgc3ViamVjdFNjaGVtZT0iRk9SIj42MDUwNiBWaXJvbG9neTwvc3ViamVjdD4KICAgIDxzdWJqZWN0PkdlbmV0aWNzPC9zdWJqZWN0PgogICAgPHN1YmplY3Qgc2NoZW1lVVJJPSJodHRwOi8vd3d3LmFicy5nb3YuYXUvYXVzc3RhdHMvYWJzQC5uc2YvMC82QkI0MjdBQjk2OTZDMjI1Q0EyNTc0MTgwMDA0NDYzRSIgc3ViamVjdFNjaGVtZT0iRk9SIj4xMTAzMDkgSW5mZWN0aW91cyBEaXNlYXNlczwvc3ViamVjdD4KICAgIDxzdWJqZWN0PkltbXVub2xvZ3k8L3N1YmplY3Q+CiAgPC9zdWJqZWN0cz4KICA8cHVibGlzaGVyPmZpZ3NoYXJlPC9wdWJsaXNoZXI+CiAgPHB1YmxpY2F0aW9uWWVhcj4yMDEzPC9wdWJsaWNhdGlvblllYXI+CiAgPGRhdGVzPgogICAgPGRhdGUgZGF0ZVR5cGU9IkNyZWF0ZWQiPjIwMTMtMDgtMDk8L2RhdGU+CiAgICA8ZGF0ZSBkYXRlVHlwZT0iVXBkYXRlZCI+MjAxNi0wOC0zMDwvZGF0ZT4KICA8L2RhdGVzPgogIDxyZXNvdXJjZVR5cGUgcmVzb3VyY2VUeXBlR2VuZXJhbD0iRGF0YXNldCI+RGF0YXNldDwvcmVzb3VyY2VUeXBlPgogIDxzaXplcz4KICAgIDxzaXplPjQ0MDEyOSBCeXRlczwvc2l6ZT4KICA8L3NpemVzPgogIDxyaWdodHNMaXN0PgogICAgPHJpZ2h0cyByaWdodHNVUkk9Imh0dHBzOi8vY3JlYXRpdmVjb21tb25zLm9yZy9saWNlbnNlcy9ieS80LjAvIj5DQyBCWSA0LjA8L3JpZ2h0cz4KICA8L3JpZ2h0c0xpc3Q+CjwvcmVzb3VyY2U+","url":"https://figshare.com/articles/dataset/Multi_parametric_comparative_analysis_of_all_pre_and_post_infection_related_immune_cell_and_clinical_traits/768435","contentUrl":null,"metadataVersion":2,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2013-09-11T15:09:28.000Z","registered":"2013-09-11T15:09:29.000Z","published":"2013","updated"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