{"data":{"id":"10.6084/m9.figshare.7677299","type":"dois","attributes":{"doi":"10.6084/m9.figshare.7677299","prefix":"10.6084","suffix":"m9.figshare.7677299","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Thais Aragão Horoiwa","affiliation":[],"nameIdentifiers":[]},{"name":"Oliveira, Adriano Marim De","nameType":"Personal","givenName":"Adriano Marim De","familyName":"Oliveira","affiliation":[],"nameIdentifiers":[]},{"name":"Migotto, Amanda","nameType":"Personal","givenName":"Amanda","familyName":"Migotto","affiliation":[],"nameIdentifiers":[]},{"name":"Cerize, Natalia Neto Pereira","nameType":"Personal","givenName":"Natalia Neto Pereira","familyName":"Cerize","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Process Evaluation of Sugar-Based Polymeric Colloidal Nanocarrier Formation"}],"publisher":"SciELO journals","container":{},"publicationYear":2019,"subjects":[{"subject":"90499 Chemical Engineering not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical engineering","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical engineering","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"91207 Metals and Alloy Materials","subjectScheme":"FOR"},{"subject":"FOS: Materials engineering","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Materials engineering","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"91299 Materials Engineering not elsewhere classified","subjectScheme":"FOR"}],"contributors":[],"dates":[{"date":"2019-02-06","dateType":"Created"},{"date":"2019-02-06","dateType":"Updated"},{"date":"2019","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1590/1980-5373-mr-2018-0074","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["3130404 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Abstract Several studies have demonstrated that sugar-based nanocarriers are recommended to develop drug delivery systems since they are biocompatible and biodegradable and might improve the therapeutic index of currently used drugs by reducing their toxicity and enhancing their bioavailability. Therewith, this work studied the processing conditions to formation of a sugar-based nanocarrier denominated polymeric colloidal nanocarriers (PCN). It reports the impact of emulsifiers types and concentration, salt concentration and copolymers addition on physical stability and particle size distribution of a maltodextin-based PCN. In order to define the most stable formulation to produce the maltodextrin nanocarriers, 13 PCN formulations were evaluated in respect to kinetic stability, particle size distribution and morphology. The results demonstrated that to have a stable sugar-based PCN in silicone for at least 3 days, it is necessary to work with Poloxamer 188 as a copolymer, SF 1540 surfactant in a concentration proportional to the solid content and a salt concentration of 0.4 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