{"data":{"id":"10.6084/m9.figshare.7653227","type":"dois","attributes":{"doi":"10.6084/m9.figshare.7653227","prefix":"10.6084","suffix":"m9.figshare.7653227","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Z. Schultzhaus","affiliation":[],"nameIdentifiers":[]},{"name":"G. A. Cunningham","affiliation":[],"nameIdentifiers":[]},{"name":"R. R. Mouriño-Pérez","affiliation":[],"nameIdentifiers":[]},{"name":"B. D. Shaw","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"The phospholipid flippase DnfD localizes to late Golgi and is involved in asexual differentiation in \u003ci\u003eAspergillus nidulans\u003c/i\u003e"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2019,"subjects":[{"subject":"Biophysics"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Microbiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"Physiology"},{"subject":"Developmental Biology"},{"subject":"Plant Biology"},{"subject":"Computational Biology"}],"contributors":[],"dates":[{"date":"2019-01-30","dateType":"Created"},{"date":"2019-02-25","dateType":"Updated"},{"date":"2019","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/00275514.2018.1543927","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["14492699 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"The maintenance of cell shape requires finely tuned and robust vesicle trafficking in order to provide sufficient plasma membrane materials. The hyphal cells of filamentous fungi are an extreme example of cell shape maintenance due to their ability to grow rapidly and respond to the environment while keeping a relatively consistent shape. We have previously shown that two phospholipid flippases, which regulate the asymmetry of specific phospholipids within the plasma membrane, are important for hyphal growth in \u003ci\u003eAspergillus nidulans\u003c/i\u003e. Here, we examine the rest of the phospholipid flippases encoded by \u003ci\u003eA. nidulans\u003c/i\u003e by obtaining single and double deletions of all four family members, \u003ci\u003ednfA, dnfB, dnfC\u003c/i\u003e, and \u003ci\u003ednfD\u003c/i\u003e. We find that deleting \u003ci\u003ednfC\u003c/i\u003e does not impart a noticeable phenotype, by itself or with other deletions, but that \u003ci\u003ednfD\u003c/i\u003e, the homolog of the essential yeast gene \u003ci\u003eneo1\u003c/i\u003e, is important for conidiation. \u003ci\u003ednfD\u003c/i\u003e deletion mutants form misshapen conidiophore vesicles that are defective in metulae formation. We localize DnfD to late Golgi equivalents, where it appears just before dissociation of this organelle. We propose that DnfD functions in a trafficking process that is specifically required for the morphological changes that take place during conidiation.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/articles/The_phospholipid_flippase_DnfD_localizes_to_late_Golgi_and_is_involved_in_asexual_differentiation_in_i_Aspergillus_nidulans_i_/7653227","contentUrl":null,"met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