{"data":{"id":"10.6084/m9.figshare.7637504.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.7637504.v1","prefix":"10.6084","suffix":"m9.figshare.7637504.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Liang, Ning","nameType":"Personal","givenName":"Ning","familyName":"Liang","affiliation":[],"nameIdentifiers":[]},{"name":"Anastasius Damdimopoulos","affiliation":[],"nameIdentifiers":[]},{"name":"Saioa Goñi","affiliation":[],"nameIdentifiers":[]},{"name":"Giudici, Marco","nameType":"Personal","givenName":"Marco","familyName":"Giudici","affiliation":[],"nameIdentifiers":[]},{"name":"Zhiqiang Huang","affiliation":[],"nameIdentifiers":[]},{"name":"Lise-Lotte Vedin","affiliation":[],"nameIdentifiers":[]},{"name":"Jakobsson, Tomas","nameType":"Personal","givenName":"Tomas","familyName":"Jakobsson","affiliation":[],"nameIdentifiers":[]},{"name":"Ahmed, Osman","nameType":"Personal","givenName":"Osman","familyName":"Ahmed","affiliation":[],"nameIdentifiers":[]},{"name":"Pedrelli, Matteo","nameType":"Personal","givenName":"Matteo","familyName":"Pedrelli","affiliation":[],"nameIdentifiers":[]},{"name":"Barilla, Serena","nameType":"Personal","givenName":"Serena","familyName":"Barilla","affiliation":[],"nameIdentifiers":[]},{"name":"Alzaid, Fawaz","nameType":"Personal","givenName":"Fawaz","familyName":"Alzaid","affiliation":[],"nameIdentifiers":[]},{"name":"Mendoza, Arturo","nameType":"Personal","givenName":"Arturo","familyName":"Mendoza","affiliation":[],"nameIdentifiers":[]},{"name":"Schröder, Tarja","nameType":"Personal","givenName":"Tarja","familyName":"Schröder","affiliation":[],"nameIdentifiers":[]},{"name":"Kuiper, Raoul","nameType":"Personal","givenName":"Raoul","familyName":"Kuiper","affiliation":[],"nameIdentifiers":[]},{"name":"Parini, Paolo","nameType":"Personal","givenName":"Paolo","familyName":"Parini","affiliation":[],"nameIdentifiers":[]},{"name":"Hollenberg, Anthony","nameType":"Personal","givenName":"Anthony","familyName":"Hollenberg","affiliation":[],"nameIdentifiers":[]},{"name":"Lefebvre, Philippe","nameType":"Personal","givenName":"Philippe","familyName":"Lefebvre","affiliation":[],"nameIdentifiers":[]},{"name":"Francque, Sven","nameType":"Personal","givenName":"Sven","familyName":"Francque","affiliation":[],"nameIdentifiers":[]},{"name":"Gaal, Luc Van","nameType":"Personal","givenName":"Luc Van","familyName":"Gaal","affiliation":[],"nameIdentifiers":[]},{"name":"Staels, Bart","nameType":"Personal","givenName":"Bart","familyName":"Staels","affiliation":[],"nameIdentifiers":[]},{"name":"Venteclef, Nicolas","nameType":"Personal","givenName":"Nicolas","familyName":"Venteclef","affiliation":[],"nameIdentifiers":[]},{"name":"Treuter, Eckardt","nameType":"Personal","givenName":"Eckardt","familyName":"Treuter","affiliation":[],"nameIdentifiers":[]},{"name":"Rongrong Fan","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα"}],"publisher":"figshare","container":{},"publicationYear":2019,"subjects":[{"subject":"111601 Cell Physiology","subjectScheme":"FOR"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Basic medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"110306 Endocrinology","subjectScheme":"FOR"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Diseases"},{"subject":"110307 Gastroenterology and Hepatology","subjectScheme":"FOR"},{"subject":"110104 Medical Biochemistry: Lipids","subjectScheme":"FOR"},{"subject":"110107 Metabolic Medicine","subjectScheme":"FOR"},{"subject":"111207 Molecular Targets","subjectScheme":"FOR"}],"contributors":[],"dates":[{"date":"2019-01-28","dateType":"Created"},{"date":"2019-01-28","dateType":"Updated"},{"date":"2019","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsPreviousVersionOf","relatedIdentifier":"10.6084/m9.figshare.7637504","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["135698107 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Obesity triggers the genesis of non-alcoholic fatty liver diseases (NAFLD), which involves alterations of regulatory transcription networks and of hepatocyte-selective epigenomes. Here we demonstrate that G protein pathway suppressor 2 (GPS2), a subunit of the nuclear receptor corepressor (NCOR)/ histone deacetylase 3 (HDAC3) complex, is a central component of such networks and accelerates the progression of NAFLD towards non-alcoholic steatohepatitis (NASH). Hepatocyte-specific Gps2 knockout in mice alleviates the development of diet-induced steatosis and fibrosis and causes activation of lipid catabolic genes. Integrative cistrome, epigenome and transcriptome analysis identifies the lipid-sensing peroxisome proliferator-activated receptor alpha (PPARa, NR1C1) as a direct GPS2 target. Liver gene expression data from human patients reveal that GPS2 expression positively correlates with a NASH/fibrosis gene signature. Collectively, our data suggest that the GPS2-PPARa partnership in hepatocytes coordinates the progression of NAFLD in mice and in humans and thus might be therapeutically important.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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