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The simulations corresponds to 12 weeks of therapy in a luminal non-responder patient of the NeoAva clinical trial using standard and alternative schedules. Cancer, stroma cells and oxygen tension are shown. To produce the simulations we use a multiscale pharmacokinetic and pharmacodynamic model informed by individual, multisource clinical data, including histological, molecular and magnetic resonance imaging data. See reference below.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://figshare.com/articles/dataset/Personalized_computer_simulations_of_a_NeoAva_non-responder_patient_comparison_of_standard_and_alternative_schedules/5372665","contentUrl":null,"metadataVersion":2,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2017-09-03T15:42:20.000Z","registered":"2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