{"data":{"id":"10.6084/m9.figshare.5125357","type":"dois","attributes":{"doi":"10.6084/m9.figshare.5125357","prefix":"10.6084","suffix":"m9.figshare.5125357","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Yang, X.-Y.","nameType":"Personal","givenName":"X.-Y.","familyName":"Yang","affiliation":[],"nameIdentifiers":[]},{"name":"Wu, W.-J.","nameType":"Personal","givenName":"W.-J.","familyName":"Wu","affiliation":[],"nameIdentifiers":[]},{"name":"Yang, C.","nameType":"Personal","givenName":"C.","familyName":"Yang","affiliation":[],"nameIdentifiers":[]},{"name":"Yang, T.","nameType":"Personal","givenName":"T.","familyName":"Yang","affiliation":[],"nameIdentifiers":[]},{"name":"He, J.-D.","nameType":"Personal","givenName":"J.-D.","familyName":"He","affiliation":[],"nameIdentifiers":[]},{"name":"Yang, Z.","nameType":"Personal","givenName":"Z.","familyName":"Yang","affiliation":[],"nameIdentifiers":[]},{"name":"He, L.","nameType":"Personal","givenName":"L.","familyName":"He","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Supplementary Material for: Association of \u003cb\u003e\u003ci\u003eHSD17B3\u003c/i\u003e\u003c/b\u003e and \u003cb\u003e\u003ci\u003eHSD3B1\u003c/i\u003e\u003c/b\u003e Polymorphisms with Acne Vulgaris in Southwestern Han Chinese"}],"publisher":"Karger Publishers","container":{},"publicationYear":2013,"subjects":[{"subject":"Medicine"}],"contributors":[],"dates":[{"date":"2017-06-20","dateType":"Created"},{"date":"2017-06-20","dateType":"Updated"},{"date":"2013","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1159/000353581","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["50176 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Acne vulgaris is a very common skin disorder. Previous studies have indicated that genetic background factors play key roles in the onset of acne. Our previous investigation implicated several genes in the androgen metabolism pathway with acne vulgaris in the Han Chinese population. Thus, we further investigated genes and genetic variants that play important roles in this pathway for their relationship with the pathology of acne. In this study, a total of 610 subjects, including 403 acne patients and 207 healthy controls, were genotyped for 15 single-nucleotide polymorphisms in \u003ci\u003eHSD3B1\u003c/i\u003e and \u003ci\u003eHSD17B3\u003c/i\u003e genes. This study shows that rs6428829 in \u003ci\u003eHSD3B1\u003c/i\u003e was associated with acne vulgaris in Han patients from Southwest China, even after adjusting for age and sex. The GG genotype was associated with an increased risk of acne vulgaris (p \u0026lt; 0.05) and G allele carriers were associated with an increased risk of acne vulgaris (p \u0026lt; 0.05). In addition, the haplotype AAT in \u003ci\u003eHSD3B1\u003c/i\u003e significantly increased the risk of acne vulgaris in the case-control study (p \u0026lt; 0.05). Furthermore, for another gene in this pathway, \u003ci\u003eHSD17B3\u003c/i\u003e, the haplotype H8 was significantly associated with an increased risk of acne vulgaris. Based on these analyses, our study indicates that the cutaneous androgen metabolism-regulated genes \u003ci\u003eHSD3B1\u003c/i\u003e and \u003ci\u003eHSD17B3\u003c/i\u003e increase the susceptibility to acne vulgaris in Han Chinese from Southwest China.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Association_of_b_i_HSD17B3_i_b_and_b_i_HSD3B1_i_b_Polymorphisms_with_Acne_Vulgaris_in_Southwestern_Han_Chinese/5125357","contentUrl":null,"metadataVersion":2,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,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