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Results to date confirm only a few gene variants associated with longevity, while others show inconsistent results. However, GWAS studies concentrate on single nucleotide polymorphisms, and there are only a handful of studies investigating variable number of tandem repeat variations related to longevity. Recently, Grady and colleagues (2013) reported a remarkable (66%) accumulation of those carrying the 7 repeat allele of the dopamine D4 receptor gene in a large population of 90-109 years old Californian centenarians, as compared to an ancestry-matched young population. In the present study we demonstrate the same association using continuous age groups in an 18-97 years old Caucasian sample (N=1801, p=0.007). We found a continuous pattern of increase from 18-75, however frequency of allele 7 carriers decreased in our oldest age groups. Possible role of gene-environment interaction effects driven by historical events are discussed. In accordance with previous findings, we observed association preferentially in females (p=0.003). Our results underlie the importance of investigating non-disease related genetic variants as inherited components of longevity, and confirm, that the 7-repeat allele of the dopamine D4 receptor gene is a longevity enabling genetic factor, accumulating in the elderly female population.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://figshare.com/articles/dataset/Szekely2017PLoS_LongevityDatabase_sav/4272677/1","contentUrl":null,"metadataVersion":1,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":2,"viewsOverTime":[{"yearMonth":"2025-08","total":1},{"yearMonth":"2025-10","total":1}],"downloadCount":1,"downloadsOverTime":[{"yearMonth":"2025-08","total":1},{"yearMonth":"2025-10","total":0}],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2016-12-01T09:41:27.000Z","registered":"2016-12-01T09:41:27.000Z","published":"2016","updated":"2020-09-03T11:13:23.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.4272677.v1","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"ver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