{"data":{"id":"10.6084/m9.figshare.3984480","type":"dois","attributes":{"doi":"10.6084/m9.figshare.3984480","prefix":"10.6084","suffix":"m9.figshare.3984480","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Yihui Liu","affiliation":[],"nameIdentifiers":[]},{"name":"Jin, Long","nameType":"Personal","givenName":"Long","familyName":"Jin","affiliation":[],"nameIdentifiers":[]},{"name":"Pengbo Lou","affiliation":[],"nameIdentifiers":[]},{"name":"Yiren Gu","affiliation":[],"nameIdentifiers":[]},{"name":"Mingzhou Li","affiliation":[],"nameIdentifiers":[]},{"name":"Xuewei Li","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Dynamic microRNAome profiles in the developing porcine liver"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2016,"subjects":[{"subject":"Biophysics"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Medicine"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Physiology"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Ecology"},{"subject":"69999 Biological Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"Developmental Biology"},{"subject":"Plant Biology"},{"subject":"Computational Biology"}],"contributors":[],"dates":[{"date":"2016-10-05","dateType":"Created"},{"date":"2018-03-08","dateType":"Updated"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/09168451.2016.1240602","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["2302732 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Increasing evidence suggests that micro (mi)RNAs play important roles in various biological process. To evaluate the roles of miRNA in the porcine liver, we investigated the dynamic profiles of microRNAomes using liver tissue from pigs during the embryonic period (embryonic day 90), weaning stage (postnatal day 30), and adult stage (7 years old). A total of 186 unique miRNAs were differentially expressed during liver development. We also identified that 17, 13, and 6 miRNAs were specifically abundant at embryonic day 90, postnatal day 30, and at 7 years, respectively. Besides regulating basic cellular roles in development, miRNAs expressed at the three developmental stages also participated in regulating “embryonic liver development,” “early hepatic growth and generating a functioning liver,” and “energy metabolic processes,” respectively. Our study indicates that miRNAs are extensively involved in liver development, and provides a valuable resource for the further elucidation of miRNA regulatory roles during liver development. miRNAs are extensively involved in liver development, especially for these stage-enriched miRNAs.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":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