{"data":{"id":"10.6084/m9.figshare.3806643","type":"dois","attributes":{"doi":"10.6084/m9.figshare.3806643","prefix":"10.6084","suffix":"m9.figshare.3806643","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Gebre-Medhin, Maria","nameType":"Personal","givenName":"Maria","familyName":"Gebre-Medhin","affiliation":[],"nameIdentifiers":[]},{"name":"Haghanegi, Mahnaz","nameType":"Personal","givenName":"Mahnaz","familyName":"Haghanegi","affiliation":[],"nameIdentifiers":[]},{"name":"Robért, Lotta","nameType":"Personal","givenName":"Lotta","familyName":"Robért","affiliation":[],"nameIdentifiers":[]},{"name":"Kjellén, Elisabeth","nameType":"Personal","givenName":"Elisabeth","familyName":"Kjellén","affiliation":[],"nameIdentifiers":[]},{"name":"Nilsson, Per","nameType":"Personal","givenName":"Per","familyName":"Nilsson","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Dose-volume analysis of radiation-induced trismus in head and neck cancer patients"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2016,"subjects":[{"subject":"Biophysics"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Medicine"},{"subject":"Cell Biology"},{"subject":"69999 Biological Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cancer"},{"subject":"Science Policy"},{"subject":"Hematology"}],"contributors":[],"dates":[{"date":"2016-09-05","dateType":"Created"},{"date":"2017-05-25","dateType":"Updated"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/0284186x.2016.1221129","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["2372921 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"\u003cb\u003eIntroduction:\u003c/b\u003e Trismus is a treatment-related late side effect in patients treated for cancer in the head and neck region (HNC). The condition can have a considerable negative impact on nutrition, dental hygiene, ability to speak and quality of life. We have previously studied trismus within the frame of a randomized phase 3 study of HNC patients treated with mainly three-dimensional (3D) conformal radiotherapy (CRT) and found a strong association to mean radiation dose to the mastication muscles, especially the ipsilateral masseter muscle (\u003ci\u003ei\u003c/i\u003eMAS). In the present study we have investigated trismus prevalence and risk factors in a more recent cohort of patients, treated with todays’ more updated radiation techniques. \u003cb\u003eMaterial and methods:\u003c/b\u003e Maximal interincisal distance (MID) was measured on 139 consecutive patients. Trismus was defined as MID ≤35 mm. Patient-, disease- and treatment-specific data were retrospectively recorded. Differences between groups were analyzed and mean absorbed dose to mastication structures was evaluated. Dosimetric comparisons were made between this study and our previous results. \u003cb\u003eResults:\u003c/b\u003e The prevalence of trismus was 24% at a median of 16 months after completion of radiotherapy. In bivariate analysis treatment technique (3DCRT vs. intensity modulated radiotherapy or helical tomotherapy), tumor site (oropharynx vs. other sites) and mean radiation doses to the ipsilateral lateral pterygoid muscle, the paired masseter muscles and the \u003ci\u003ei\u003c/i\u003eMAS were significantly associated with MID ≤35 mm. In multivariable analysis only mean radiation dose to the \u003ci\u003ei\u003c/i\u003eMAS was significantly associated to MID ≤35 mm. \u003cb\u003eConclusion:\u003c/b\u003e Mean radiation dose to the ipsilateral masseter muscle is an important risk factor for trismus development. Dose reduction to this structure during radiotherapy should have a potential to diminish the prevalence of trismus in this patient 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