{"data":{"id":"10.6084/m9.figshare.3764379.v2","type":"dois","attributes":{"doi":"10.6084/m9.figshare.3764379.v2","prefix":"10.6084","suffix":"m9.figshare.3764379.v2","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Caglar, Sema","nameType":"Personal","givenName":"Sema","familyName":"Caglar","affiliation":[],"nameIdentifiers":[]},{"name":"Dilek, Esra","nameType":"Personal","givenName":"Esra","familyName":"Dilek","affiliation":[],"nameIdentifiers":[]},{"name":"Bulent Caglar","affiliation":[],"nameIdentifiers":[]},{"name":"Adiguzel, Ekrem","nameType":"Personal","givenName":"Ekrem","familyName":"Adiguzel","affiliation":[],"nameIdentifiers":[]},{"name":"Temel, Ersin","nameType":"Personal","givenName":"Ersin","familyName":"Temel","affiliation":[],"nameIdentifiers":[]},{"name":"Buyukgungor, Orhan","nameType":"Personal","givenName":"Orhan","familyName":"Buyukgungor","affiliation":[],"nameIdentifiers":[]},{"name":"Tabak, Ahmet","nameType":"Personal","givenName":"Ahmet","familyName":"Tabak","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"New metal complexes with diclofenac containing 2-pyridineethanol or 2-pyridinepropanol: synthesis, structural, spectroscopic, thermal properties, catechol oxidase and carbonic anhydrase activities"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2016,"subjects":[{"subject":"Biophysics"},{"subject":"Biochemistry"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"Physiology"},{"subject":"Pharmacology"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Marine Biology"}],"contributors":[],"dates":[{"date":"2016-09-05","dateType":"Created"},{"date":"2016-10-06","dateType":"Updated"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/00958972.2016.1227802","relatedIdentifierType":"DOI"},{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.3764379","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["7384481 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Four new neutral diclofenac-based complexes, [Co(dicl)2(2-pyet)2] 1, [Ni(dicl)2(2-pyet)2] 2, [Cu2(dicl)2(2-pyet)2] 3, and [Cu2(dicl)2(2-pypr)2] 4 have been synthesized and characterized by elemental analysis, FT-IR, thermal analysis. Complexes 1, 3, and 4 have also been characterized by X-ray single-crystal structural analysis. The compounds of Co(II) and Ni(II) have octahedral geometry with two diclofenac and two 2-pyridineethanol ligands in the coordination sphere. The compounds of Cu(II) have square-pyramidal geometry and Cu(II) ions are linked via oxygens to the bridging 2-pyridineethanol or 2-pyridinepropanol ligands. The Δν values acquired by FT-IR are in agreement with the single XRD data. Studies on the thermal properties are reported and the complexes are stable to 196, 216, 215, and 201 °C in air, respectively. Two dinuclear Cu(II) complexes have demonstrated catalytic activity on oxidation of 3,5-di-tert-butylcatechol to 3,5-di-tert-butylquinone showing saturation kinetics at high substrate concentrations. The diclofenac complexes are investigated as inhibitors of the human cytosolic isoforms hCA I and II. The complexes are good as hCA I inhibitors (Kis of 1.52–55.06 μM) but only moderately efficient as hCA II inhibitors (Kis of 0.23–5.61 μM).","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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