{"data":{"id":"10.6084/m9.figshare.3764379.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.3764379.v1","prefix":"10.6084","suffix":"m9.figshare.3764379.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Caglar, Sema","nameType":"Personal","givenName":"Sema","familyName":"Caglar","affiliation":[],"nameIdentifiers":[]},{"name":"Dilek, Esra","nameType":"Personal","givenName":"Esra","familyName":"Dilek","affiliation":[],"nameIdentifiers":[]},{"name":"Bulent Caglar","affiliation":[],"nameIdentifiers":[]},{"name":"Adiguzel, Ekrem","nameType":"Personal","givenName":"Ekrem","familyName":"Adiguzel","affiliation":[],"nameIdentifiers":[]},{"name":"Temel, Ersin","nameType":"Personal","givenName":"Ersin","familyName":"Temel","affiliation":[],"nameIdentifiers":[]},{"name":"Buyukgungor, Orhan","nameType":"Personal","givenName":"Orhan","familyName":"Buyukgungor","affiliation":[],"nameIdentifiers":[]},{"name":"Tabak, Ahmet","nameType":"Personal","givenName":"Ahmet","familyName":"Tabak","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"New metal complexes with diclofenac containing 2-pyridineethanol or 2-pyridinepropanol: Synthesis, structural, spectroscopic, thermal properties, catechol oxidase and carbonic anhydrase activities"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2016,"subjects":[{"subject":"Biophysics"},{"subject":"Biochemistry"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"Physiology"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Marine Biology"}],"contributors":[],"dates":[{"date":"2016-08-26","dateType":"Created"},{"date":"2016-08-26","dateType":"Updated"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/00958972.2016.1227802","relatedIdentifierType":"DOI"},{"relationType":"IsPreviousVersionOf","relatedIdentifier":"10.6084/m9.figshare.3764379","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["7384481 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Four new neutral diclofenac-based complexes, [Co(dicl)\u003csub\u003e2\u003c/sub\u003e(2-pyet)\u003csub\u003e2\u003c/sub\u003e] \u003cb\u003e1\u003c/b\u003e, [Ni(dicl)\u003csub\u003e2\u003c/sub\u003e(2-pyet)\u003csub\u003e2\u003c/sub\u003e] \u003cb\u003e2,\u003c/b\u003e [Cu\u003csub\u003e2\u003c/sub\u003e(dicl)\u003csub\u003e2\u003c/sub\u003e(2-pyet)\u003csub\u003e2\u003c/sub\u003e] \u003cb\u003e3\u003c/b\u003e and [Cu\u003csub\u003e2\u003c/sub\u003e(dicl)\u003csub\u003e2\u003c/sub\u003e(2-pypr)\u003csub\u003e2\u003c/sub\u003e] \u003cb\u003e4\u003c/b\u003e have been synthesized and characterized by elemental analysis, FT-IR, thermal analysis. Complexes \u003cb\u003e1\u003c/b\u003e, \u003cb\u003e3\u003c/b\u003e and \u003cb\u003e4\u003c/b\u003e have also been characterized by X-ray single crystal structural analysis. The compounds of Co(II) and Ni(II) have octahedral geometry with two diclofenac and two 2-pyridineethanol ligands in the coordination sphere. The compounds of Cu(II) have square-pyramidal geometry and Cu(II) ions are linked via oxygens to the bridging 2-pyridineethanol or 2-pyridinepropanol ligands. The Δ\u003ci\u003eν\u003c/i\u003e values acquired by FT-IR are in agreement with the single XRD data. Studies on the thermal properties are reported and the complexes are stable to 196, 216, 215 and 201°C in air, respectively. Two dinuclear Cu(II) complexes have demonstrated catalytic activity on oxidation of 3,5-di-\u003ci\u003etert-\u003c/i\u003ebutylcatechol to 3,5-di-\u003ci\u003etert\u003c/i\u003e-butylquinone showing saturation kinetics at high substrate concentrations. The diclofenac complexes are investigated as inhibitors of the human cytosolic isoforms hCA I and II. The complexes are good as hCA I inhibitors (K\u003csub\u003ei\u003c/sub\u003es of 1.52-55.06 μM) but only moderately efficient as hCA II inhibitors (K\u003csub\u003ei\u003c/sub\u003es of 0.23-5.61 μM).","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/articles/dataset/New_metal_complexes_with_diclofenac_containing_2-pyridineethanol_or_2-pyridinepropanol_Synthesis_structural_spectroscopic_thermal_properties_catechol_oxidase_and_carbonic_anhydrase_activities/3764379/1","contentUrl":null,"metadataVersion":4,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":1,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2016-08-26T14:51:03.000Z","registered":"2016-08-26T14:51:04.000Z","published":"2016","updated":"2020-09-03T16:39:07.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.3764379.v1","type":"media"}},"references":{"data":[{"id":"10.1080/00958972.2016.1227802","type":"dois"}]},"citations":{"data":[]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}