{"data":{"id":"10.6084/m9.figshare.3573489.v2","type":"dois","attributes":{"doi":"10.6084/m9.figshare.3573489.v2","prefix":"10.6084","suffix":"m9.figshare.3573489.v2","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Sangyoon J. Han","affiliation":[],"nameIdentifiers":[]},{"name":"Rodriguez, Marita L.","nameType":"Personal","givenName":"Marita L.","familyName":"Rodriguez","affiliation":[],"nameIdentifiers":[]},{"name":"Al-Rekabi, Zeinab","nameType":"Personal","givenName":"Zeinab","familyName":"Al-Rekabi","affiliation":[],"nameIdentifiers":[]},{"name":"Sniadecki, Nathan J.","nameType":"Personal","givenName":"Nathan J.","familyName":"Sniadecki","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Spatial and temporal coordination of traction forces in one-dimensional cell migration"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2016,"subjects":[{"subject":"Biophysics"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Physiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"59999 Environmental Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Earth and related environmental sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Earth and related environmental sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Ecology"},{"subject":"69999 Biological Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"Developmental Biology"},{"subject":"Marine Biology"},{"subject":"Cancer"},{"subject":"Plasma Physics"},{"subject":"Computational Biology"}],"contributors":[],"dates":[{"date":"2016-09-02","dateType":"Created"},{"date":"2017-01-05","dateType":"Updated"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/19336918.2016.1221563","relatedIdentifierType":"DOI"},{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.3573489","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["71949927 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Migration of a fibroblast along a collagen fiber can be regarded as cell locomotion in one-dimension (1D). In this process, a cell protrudes forward, forms a new adhesion, produces traction forces, and releases its rear adhesion in order to advance itself along a path. However, how a cell coordinates its adhesion formation, traction forces, and rear release in 1D migration is unclear. Here, we studied fibroblasts migrating along a line of microposts. We found that when the front of a cell protruded onto a new micropost, the traction force produced at its front increased steadily, but did so without a temporal correlation in the force at its rear. Instead, the force at the front coordinated with a decrease in force at the micropost behind the front. A similar correlation in traction forces also occurred at the rear of a cell, where a decrease in force due to adhesion detachment corresponded to an increase in force at the micropost ahead of the rear. Analysis with a bio-chemo-mechanical model for traction forces and adhesion dynamics indicated that the observed relationship between traction forces at the front and back of a cell is possible only when cellular elasticity is lower than the elasticity of the cellular environment.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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