{"data":{"id":"10.6084/m9.figshare.3556398","type":"dois","attributes":{"doi":"10.6084/m9.figshare.3556398","prefix":"10.6084","suffix":"m9.figshare.3556398","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Makridis, Antonios","nameType":"Personal","givenName":"Antonios","familyName":"Makridis","affiliation":[],"nameIdentifiers":[]},{"name":"Tziomaki, Magdalini","nameType":"Personal","givenName":"Magdalini","familyName":"Tziomaki","affiliation":[],"nameIdentifiers":[]},{"name":"Topouridou, Konstantina","nameType":"Personal","givenName":"Konstantina","familyName":"Topouridou","affiliation":[],"nameIdentifiers":[]},{"name":"Yavropoulou, Maria P.","nameType":"Personal","givenName":"Maria P.","familyName":"Yavropoulou","affiliation":[],"nameIdentifiers":[]},{"name":"Yovos, John G.","nameType":"Personal","givenName":"John G.","familyName":"Yovos","affiliation":[],"nameIdentifiers":[]},{"name":"Orestis Kalogirou","affiliation":[],"nameIdentifiers":[]},{"name":"Samaras, Theodoros","nameType":"Personal","givenName":"Theodoros","familyName":"Samaras","affiliation":[],"nameIdentifiers":[]},{"name":"Mavroeidis Angelakeris","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"A novel strategy combining magnetic particle hyperthermia pulses with enhanced performance binary ferrite carriers for effective \u003ci\u003ein vitro\u003c/i\u003e manipulation of primary human osteogenic sarcoma cells"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2016,"subjects":[{"subject":"Biophysics"},{"subject":"Biochemistry"},{"subject":"Space Science"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Physiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Pharmacology"},{"subject":"Biotechnology"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"69999 Biological Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"Cancer"}],"contributors":[],"dates":[{"date":"2016-08-10","dateType":"Created"},{"date":"2016-09-21","dateType":"Updated"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/02656736.2016.1216183","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["822969 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"The present study examines the heating efficiency of a combination of manganese or cobalt ferrites in a binary (Co- or Mn-) ferrite nanoparticle form with magnetite, covered with citric acid to improve biocompatibility. The nanoparticle synthesis is based on the aqueous co-precipitation of proper salts, a facile, low-cost, environmentally friendly and high yield synthetic approach. By detailed structural and magnetic characterisation, the direct influence of structural and magnetic features on magnetic hyperthermia concludes to optimum heating efficiency. At a second stage, best performing magnetic nanoparticles undergo \u003ci\u003ein vitro\u003c/i\u003e testing in three cell lines: one cancer cell line and two reference healthy cell lines. Both binary ferrite (MnFe\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e/Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e and CoFe\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e/Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e) appear to be internalised and well tolerated by the cells while a versatile hyperthermia protocol is attempted in an effort to further improve their \u003ci\u003ein vitro\u003c/i\u003e performance. Within this protocol, hyperthermia sequences are split in two runs with an intermediate 48 h time interval cell incubation stage while in each run a variable field mode (single or multiple pulses) is applied. Single-pulse field mode represents a typical hyperthermia application scheme where cells undergo the thermal shock continuously. On the other hand multiple-pulses mode refers to multiple, much shorter in duration AC field changes (field ON/OFFs), at each hyperthermia run, resulting eventually in high heating rate and much more harmful cell treatment. Consequently, we propose a novel series of improved performance heat mediators based on ferrite structures which show maximum efficiency at cancer cells when combined with a versatile multiple-pulse hyperthermia module.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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